نتایج جستجو برای: conjugate sequence

تعداد نتایج: 445679  

1995
R. C. Brower T. Ivanenko A. R. Levi K. N. Orginos

In Hybrid Monte Carlo simulations for full QCD, the gauge fields evolve smoothly as a function of Molecular Dynamics time. Here we investigate improved methods of estimating the trial or starting solutions for the Dirac matrix inversion as superpositions of a chronological sequence of solutions in the recent past. By taking as the trial solution the vector which minimizes the residual in the li...

2007
N. L. Mironova D. V. Pyshnyi D. V. Shtadler A. A. Fedorova V. V. Vlassov M. A. Zenkova

Recently, artificial ribonucleases (aRNases)--conjugates of oligodeoxyribonucleotides and peptide (LR)(4)-G-amide--were designed and assessed in terms of the activity and specificity of RNA cleavage. The conjugates were shown to cleave RNA at Pyr-A and G-X sequences. Variations of oligonucleotide length and sequence, peptide and linker structure led to the development of conjugates exhibiting G...

2004
J. V. Breakwell

A minimal sufficient condition for global optimality involving the Darboux point, analogous to the minimal sufficient condition of local optimality involving the conjugate point, is presented. The Darboux point is then characterized for optimal control problems with linear dynamics, cost functionals with a general terminal state term and an integrand quadratic in the state and control, and gene...

Journal: :Comp. Opt. and Appl. 2004
D. Byatt I. D. Coope C. J. Price

Several recent papers have proposed the use of grids for solving unconstrained optimisation problems. Grid-based methods typically ge:nerate a sequence of grid local minimisers which converge to stationary points under mild conditions. The location and number of grid local minimisers is calculated for strictly convex quadratic functions in two dimensions with certain types of grids. These calcu...

Journal: :Clinical chemistry 1993
R Devlin R M Studholme W B Dandliker E Fahy K Blumeyer S S Ghosh

We describe a transient-state polarized fluorescence-based method for detecting nucleic acids. An active ester of the phthalocyanine dye La Jolla Blue was coupled to an oligonucleotide containing an amino group at its 5' end, and the conjugate was purified by HPLC chromatography. We monitored the hybridization characteristics of the conjugate with complementary oligonucleotides and RNA as targe...

Journal: :Neurocomputing 2011
Jian Wang Wei Wu Jacek M. Zurada

Conjugate gradient methods have many advantages in real numerical experiments, such as fast convergence and low memory requirements. This paper considers a class of conjugate gradient learning methods for backpropagation (BP) neural networks with three layers. We propose a new learning algorithm for almost cyclic BP neural networks based on PRP conjugate gradient method. We then establish the d...

2007
Wei Jie Qin Lin Yue Lanry Yung

Sequence-specific DNA detection is important in various biomedical applications such as gene expression profiling, disease diagnosis and treatment, drug discovery and forensic analysis. Here we report a gold nanoparticle-based method that allows DNA detection and quantification and is capable of single nucleotide polymorphism (SNP) discrimination. The precise quantification of single-stranded D...

Journal: :Talanta 2002
Masamichi Nakayama Toshihiro Ihara Koji Nakano Mizuo Maeda

Using the redox-active DNA conjugate (ferrocene-modified oligonucleotide 12 mer) as a probe, the novel electrochemical gene sensor, which is sensitive, convenient, and not relying on radio isotope, has been developed. Oligonucleotide (16 mer) complementary to the target (19 mer) was immobilized onto gold electrode through the specific chemisorption of successive phosphorothioates which were int...

Global Krylov subspace methods are the most efficient and robust methods to solve generalized coupled Sylvester matrix equation. In this paper, we propose the nested splitting conjugate gradient process for solving this equation. This method has inner and outer iterations, which employs the generalized conjugate gradient method as an inner iteration to approximate each outer iterate, while each...

2010
Andrew C. Flick Maria José Arevalo Caballero Albert Padwa

An efficient stereocontrolled route to ( )-cylindricine C is described. Reaction of 9-hydroxynon-1-en-5one oxime with 2,3-bis(phenylsulfonyl)-1,3-butadiene affords a 7-oxa-1-azanorbornane cycloadduct in high yield. The formation of the bicyclic isoxazolidine arises from conjugate addition of the oxime onto the diene to give a transient nitrone that spontaneously undergoes an intramolecular dipo...

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