نتایج جستجو برای: conformationally restricted
تعداد نتایج: 119548 فیلتر نتایج به سال:
The conformationally restricted adenine nucleotide analogs 8,3'anhydro-8-oxy-9-(beta-D-xylofuranosyl)adenine-5'-O-tri(di)-phosphate (I), and 8,2'-anhydro-8-oxy-9-(beta-D-arabinofuranosyl) adenine-5'-O-tri(di)-phosphate (II), were prepared chemically as their alpha-32P-labelled compounds and compared with syn-structured 8-bromo AT(D)P in mitochondrial adenine nucleotide translocation. The experi...
A second generation of a substrate-selective dynamic supramolecular catalytic system consisting of a catalyst part and a receptor part, connected by a hydrogen-bonding motif, has been realized based on rational design. The results from analyses of the equilibrium mixture of the species generated by the components of the first generation system led us to selectively lock the cisoid conformation ...
In principle, the development of the active analog approach to computer-assisted drug design can offer a unique opportunity for dramatically increasing the efficiency of designing new drug candidates by predicting the biologically active conformation of peptide ligands.1 But how do we know that such molecular modeling predictions are accurate, and can a specific set of chemical probes be develo...
Intramolecular [2+2] photocycloaddition reactions of diversely substituted N-Boc protected 4-(allylaminomethyl)-2(5H)-furanones resulted in rigid products (53-75%) with three spatially defined positions for further functionalisation.
Vesicles composed of a phosphatidylethanolamine derivative with a cyclopropyl-containing interfacial region are twenty-seven times less permeable than vesicles composed of a closely related analogue.
We prepared a novel series of conformationally restricted bicyclonucleosides and nucleotides. The synthetic approach employed a ring closing metathesis to provide access to both 6 and 7 membered saturated and unsaturated rings linking the 3' to 5' methylene groups of the sugar. The bicyclonucleosides were also transformed to the corresponding phosphoramidate prodrugs by an innovative one-pot pr...
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