Objective(s):In this study, we aimed at evaluation of electrophysiological and histopathalogical characteristics of statin-induced muscle injury as well as clinical features of patients who develop this condition in terms of frequency and pattern of evolution. Materials and Methods: Forty patients (age 39-74 years) including 25 subjects with type 2 diabetes mellitus, 9 with cardiovascular disea...

For one-dimensional propagation, a nonlinear relationship between Vmax and conduction velocity is predicted by cable theory, and, under experimental conditions, Vmax and conduction velocity may change in opposite directions. Using standard microelectrode techniques, we have measured Vmax and conduction velocity in guinea pig papillary muscles exposed to tetrodotoxin and low sodium (agents expec...

Change in transmitting time of impulses along axons is traditionally attributed to two parameters: the myelin formation and the diameter of neurite, both rising during the postnatal development. In the previous study, we showed that conduction velocity of the fibers projecting from the thalamus to the layer IV of the somatosensory (barrel) cortex increases as a function of age. However, the con...

The conduction velocity of peripheral neurons recorded by wire microelectrodes implanted in intact, freely moving cats was determined on-line using the technique of spike-triggered averaging of nerve cuff electrode records described here. Axonal velocity was estimated from the conduction latency between two adjacent sets of tripolar recording electrodes inside a cuff, thereby avoiding uncertain...

OBJECTIVE Slow nerve conduction velocity and reduction in response amplitude are objective hallmarks of diabetic sensorimotor polyneuropathy. Because subjective or clinical indicators of neuropathy do not always match well with the presence of abnormal nerve physiology tests, we evaluated associations to nerve conduction in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Nerve cond...

Although measurements of nerve conduction velocity in man were first made nearly a hundred years ago, the procedure was not used clinically until 1948 when Hodes, Larrabee, and German reported reduced conduction velocity in regenerating motor nerves. Later, Hodes (1949) described slow conduction in surviving nerve fibres after poliomyelitis, and more recently it has been shown that conduction m...