Dr. Colmar Niederstadt, Department of Internal Medicine, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck (Germany) From days 4-18 after intoxication, we repeatedly measured the urinary concentration of immunoglobulin G, albumin, < xi-microglobulin and endogenous creatinine clearance (fig. 1). Ethylene glycol itself is probably not nephrotoxic, but in the metabolism of ethyle...

Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylen...

frothers havea profoundeffectonbubble size and also flotation efficiency. in present study the effect of type and dosage of frothers on the flotation response of coarse particles of quartz was investigated.  therefore, flotation response of coarse particles using frothers such as mibc, pine oil, poly propylene glycol with concentration of 0, 25, 50 and 75 g/t, was obtained respectively. for all...

Glioblastoma multiforme (GBM) is a highly advanced and invasive brain tumor due to which current treatments cannot completely treat GBM or prevent recurrence. Therefore, adjunctive treatments are required. As part of the invasive and angiogenic nature of GBM, it has been well established that matrix metalloprotease-2 (MMP-2) and MMP-9 are overactive. To better treat GBM using chemotherapy, we h...

The ability to control the interaction between proteins and cells with biomaterials is critical for the effective application of materials for a variety of biomedical applications. Herein, the surface modification of the biological dopant dextran sulphate-doped polypyrrole (PPy-DS) with poly(ethylene glycol) to generate a biomaterial interface that is highly resistant to protein and cellular ad...

Highly cross-linked 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) dimethacrylate with poly(ethylene glycol) of molecular weight 600 (PEG600DMA) were molecularly imprinted with hydrophilic templates glucose and proxyphylline using water as a solvent. Glucose-imprinted polymers showed increased recognitive capacity compared to nonimprinted polymers as well as increased glucose upta...

In this work, new biodegradable ABCBA type pentablock copolymers with different mole ratio of L-lactide and PPDO-b-PEG-b-PPDO triblock copolymer were synthesized and characterized. In the first step, PPDO-b-PEG-b-PPDO triblock copolymer was synthesized via a ring-opening polymerization of P-DiOxanone (PDO) monomer with Poly (Ethylene Glycol) (P...

Poly(ethylene glycol) (PEG) is an often used crystallising agent in screening experiments for protein crystallisation conditions. To investigate the influence of poly(ethylene glycol)-4600 on the diffusion process during protein crystal growth, a series of in-situ optical microscopy experiments was performed in which the diffusion coefficient was changed by the addition of PEG. Depending on the...