In the present study, starting compound 4 was prepared by deamination of compound 2 in the presence of hypophosphorous acid and sodium nitrite. Treatment of compound 4 with ethyl bromoacetate produced ethyl[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetate (5), which was converted to the hydrazide derivative (6) by treatment with hydrazine hydrate. The reaction of compound 6 ...

The activity of the enzyme 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1), which converts inactive cortisone (11-dehydrocorticosterone (11-DHC)) (in mice) into the active glucocorticoid (GC) cortisol (corticosterone in mice), can amplify tissue GC exposure. Elevated TNFa is a common feature in a range of inflammatory disorders and is detrimental to muscle function in diseases such as rheuma...

Indirect nuclear spin-spin coupling constants J(11B,1H) and J(11B, 11B) in neutral and anionic boron hydrides 1 – 17, calculated at the B3LYP/6-311+G(d,p) level of theory, are in good agreement with experimental data if available. This is shown for [BH4]− (1), B2H6 (2), B4H10 (3), B5H9 (4), or [B2H7]− (12). The calculations can be used to obtain values for those coupling constants for which exp...

Thrombospondin (TSP), an adhesive glycoprotein, is incorporated into the extracellular matrix, mediates cell attachment and spreading, chemotaxis, haptotaxis, and may participate in the directed movement of cells in metastasis. Evidence from several model systems suggests that these functions may be mediated by different domains within the TSP molecule. Radioligand binding assays on 11B squamou...