The compression of ceramic powders requires the addition of organic materials to insure tablet cohesion. For the compaction of formulated ceramic powders it is necessary to supply them energy. As a function of the formulation of ceramic powders, one can measure the specific energy acquired during the tablet compression. Recently, a technique used in powder metallurgy, High Velocity Compaction (...

Lactose is a widely used excipient in the pharmaceutical industry. It exists as anhydrous, αand βmonohydrate forms, which can be either crystalline or amorphous. Commercially available lactose comes in various grades differentiated by physical forms as well as modifications such as particle size. These characteristic modifications enable formulation and processing. Lactose grades for direct com...

Lactose is available in several crystalline forms, which differ in binding properties. A new method of estimating the fragmentation propensity was applied to investigate the consolidation and compaction behaviour of this excipient for direct compression. Mercury porosimetry was used to demonstrate that crystalline lactose fragments during compaction. Tablet strength was found to be dependent on...

This paper introduces a finite memory compactor called convolutional compactor that provides compaction ratios of test responses in excess of 100x even for a very small number of outputs. This is combined with the capability to detect multiple errors, handling of unknown states, and the ability to diagnose failing scan cells directly from compacted responses. A convolutional compactor can be ea...

In one form of powder methods, the powder is compressed in a die and subsequently sintered. The final dimensions are determined by the powder, die, compaction pressure, and sintering densification cycle. The higher the compaction pressure, the higher the final density and properties. Minimal densification occurs in sintering if the powders are large and the sintering temperature is low. This is...

The present a novel class of multidimensional orthogonal FM transforms. The analysis suggests a novel signal-adaptive FM transform possessing interesting energy compaction properties. We show that the proposed signal-adaptive FM transform produces point spectra for multidimensional signals with uniformly distributed samples. This suggests that the proposed transform is suitable for energy compa...

Objective Eudragits are widely used polymers in the production of oral sustained release dosage forms. The application of these polymers in the production of inert insoluble matrices has been investigated. However the effect of particle size, compaction force and presence of Aerosil 200 as a glidant on the properties of Eudragit RS and RL matrices prepared by direct compression of their physic...

The aim of this project is to develop methods for scaling up roller compaction process from lab scale to pilot scale, to determine the effect of processing parameters of roller compactors at both lab scale (instrumented roller compactor at University of Birmingham, micro-pactor at Pfizer) and pilot scale (mini-pactor from Gerteis) on the attributes of dry-granulated formulations, including the ...

Tissue-engineered heart valves (TEHVs), based on polyglycolic acid (PGA) scaffolds coated with poly-4-hydroxybutyrate (P4HB), have shown promising in vivo results in terms of tissue formation. However, a major drawback of these TEHVs is compaction and retraction of the leaflets, causing regurgitation. To overcome this problem, the aim of this study was to investigate: (a) the use of the slowly ...

different additives have been considered to improve stabilization of the engineering properties of fine-grained soil. the present study investigated the effect of the addition of sewage sludge ash on the compressive strength of clay soil at optimum moisture content and under saturated conditions. the four treatments tested were the addition of 0%, 5%, 10% and 15% sewage sludge ash to clayey soi...