Colonic drug delivery has gained remarkable importance for the delivery of the drugs for the treatment of local diseases associated with the colon. To achieve successful colonic delivery, colon targeting is of prime importance. Various natural therapies, available for the treatment of colonic diseases like ulcerative colitis, Intestinal bowel syndrome, colon cancer, diverticulitis, etc., are ba...

The purpose of the present study was to formulate polymeric self-emulsifying curcumin nanocapsules with high encapsulation efficiency, good emulsification ability, and optimal globule size for localized targeting in the colon. Formulations were prepared using modified quasiemulsion solvent diffusion method. Concentration of formulation variables, namely, X1 (oil), X2 (polymeric emulsifier), and...

OBJECTIVE Neurotensin (NT) mediates colonic inflammation through its receptor neurotensin receptor 1 (NTR1). NT stimulates miR-133α expression in colonic epithelial cells. We investigated the role of miR-133α in NT-associated colonic inflammation in vitro and in vivo. DESIGN miR-133α and aftiphilin (AFTPH) levels were measured by quantitative PCR. Antisense (as)-miR-133α was administrated int...

Abstract Background The purpose of the present study was to evaluate layered satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and with a non-toxic nature composite response design 3 levels 2 factors each four responses in quadratic model. independent variables ratio consistency % (X1) level (X2) pellet. dependent release drug at h...

Systematic alanine scanning of the linear peptide bisebromoamide (BBA), isolated from a marine cyanobacterium, was enabled by solid-phase peptide synthesis of thiazole analogues. The analogues have comparable cytotoxicity (nanomolar) to that of BBA, and cellular morphology assays indicated that they target the actin cytoskeleton. Pathway inhibition in human colon tumour (HCT116) cells was explo...

The present investigation was aimed at developing a novel colon targeted system of lornoxicam based on the use of a combination of pH dependent system (to prevent the premature release of drug in the upper GIT) and enzymatically degradation system (to ensure the specificity of drug release in the colon). The drug loaded guar gum microspheres prepared by emulsification cross-linking method were ...

Colonic diverticula are outpouchings of mucosa and submucosa through the large intestine wall. Inverted colonic can be confused with adenoma. It is important to differentiate them. Here we report two cases inverted that seem like adenomas.