In 1943, while I was in the U. S. Army, a young soldier was referred to me because of gross, painless, total hematuria and a peculiarly abnormal excretion urogram. Except for this gross abnormality which looked as though a bunch of grapes were attached to each minor calyx (Fig. la and lb), no explanation could be found for his hematuria. There was no evidence of calculous disease. There was no ...

The cells of perfused rabbit collecting tubules swell and the intercellular spaces widen during osmotic flow of water from lumen to bath induced by antidiuretic hormone (ADH). Ouabain had no influence on these changes. In the absence of net water flow intercellular width was unaffected when tubules were swollen in hypotonic external media. Therefore, during ADH-induced flow widening of intercel...

We have previously shown that the transtubular potential of the rabbit cortical collecting tubule varies in concert with changes in plasma mineralocorticoid levels, while the potential of the distal convoluted tubule is invariant with such changes. In the present studies we have examined the effects of in vitro addition of d-aldosterone to isolated tubules, as well as the effects of triamterene...

Quantitative estimations of the total circumference (in mm) of Henle's thin segment (TCH) and of the collecting tubules (TCC) in the renal inner medulla of man, swine, dog and hamster were made at different distances (X) from the papillary apex. The results were expressed as exponential functions of X, the distance in mm along the medullary ray from the papillary apex to a certain point of the ...

The aim of the present study was to examine the mechanisms responsible for the antinatriuretic effect of the selective, peripherally acting, nociceptin/orphanin FQ peptide (NOP) receptor partial agonist Ac-RYYRWKKKKKKK-NH(2) (ZP120). Using immunohistochemistry, we showed that in the cortex NOP receptors are expressed in the distal convoluted tubules, the connecting tubules, and the collecting d...

The light and, to a lesser extent, the dark cells of the cortical collecting tubules in mouse kidney contain a great number of granules which according to histochemical tests are composed of phospholipids and proteins. These granules are bounded by a triple-layered membrane measuring approximately 75 A across, and contain one or several crystals with a hexagonal or square lattice. These crystal...