نتایج جستجو برای: collagenases
تعداد نتایج: 417 فیلتر نتایج به سال:
What is called osteoarthritis is the most common type of joint disease in humans. This term is doubly unsatisfactory, first because it implies that a bony abnormality, consisting of subchondral dense bone and/or osteophytes, is prominent when in fact it is often absent, and second because it does not describe a single disease. Osteoarthritis is usually used to describe the clinical and patholog...
The core of an atheromatous plaque contains lipids, macrophages, and cellular debris, typically covered by a fibrous cap that separates the thrombogenic core from the blood. Rupture of the fibrous cap causes most fatal myocardial infarctions. Interstitial collagen confers tensile strength on the cap, as it does in skin and tendons. In 1994, Peter Libby and colleagues demonstrated overexpression...
The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 m...
We describe a multimodal microscope for visualizing processive enzymes moving on immobilized substrates. The instrument combines interference reflection microscopy (IRM) with multi-wavelength total internal reflectance fluorescence (TIRFM). can localize quantum dots precision of 2.8 nm at 100 frames/s, and was used to image the dynamics cellulase, Cel7a interacting surface-immobilized cellulose...
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