Enterotoxigenic Escherichia coli (ETEC: F4) associated with post-weaning diarrhea (PWD) in pigs has developed resistance against several antimicrobial families, leading to increased use of colistin sulfate (CS) for the treatment of this disease. The objective of this study was to determine the efficacy of oral CS treatment in experimental PWD due to ETEC: F4 challenge and determine the effect o...

ObjectivesTo evaluate the efficacy of oral colistin-neomycin in preventing multidrug-resistant Enterobacterales (MDR-E) infections solid organ transplant (SOT) recipients.MethodsMulticentre, open-label, parallel-group, controlled trial with balanced (1:1) randomization five units. SOT recipients were screened for MDR-E intestinal colonization (extended-spectrum ?-lactamase or carbapenemase prod...

A simplified microbiological assay for vitamin B12 estimation, completed on microtitre plates using a colistin sulphate resistant strain of Lactobacillus leichmannii (NCIB 12519), and cryopreserved cultures is described. The new assay correlated well with a more conventional "tube" assay and was not influenced by the presence of antibiotics in serum. Evaluation of assay performance showed excel...

Sir, Ratjen et al. recently published an important paper in JAC reporting the pharmacokinetics of colistin after inhalation of colistin methanesulphonate in patients with cystic fibrosis (CF). HPLC was used to measure the concentrations of the formed colistin. The paper raises a number of important issues that deserve comment. It is important not to use the terms colistin and colistin methanesu...

Multidrug-resistant Acinetobacter baumannii has emerged as a significant clinical problem worldwide and colistin is being used increasingly as "salvage" therapy. MICs of colistin against A. baumannii indicate its significant activity. However, resistance to colistin in A. baumannii has been reported recently. Clonotypes of 16 clinical A. baumannii isolates and ATCC 19606 were determined by puls...

The global emergence and dissemination of multidrug-resistant Gram-negative superbugs, particularly carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae, lead to the limited effectiveness of antibiotics for treating nosocomial infections. In most cases, polymyxins are the last resort therapy, and these antibiotics must be used intelligently to prolong their efficacy in clinica...

Comparative tests in vitro for antibacterial activity were carried out with ampicillin, tetracycline, and chloramphenicol using 673 clinical isolates of Gram-negative bacilli and Streptococcus faecalis. Further comparative tests were also carried out with ampicillin, chloramphenicol, colistin sulphate, colistin methane sulphonate, cycloserine, kanamycin, nitrofurantoin, polymyxin, streptomycin,...

1. Arroyo L, Mateos I, González V et al. In vitro activities of tigecycline, minocycline and colistin–tigecycline combination against multiand pandrug-resistant clinical isolates of Acinetobacter baumannii group. Antimicrob Agents Chemother 2009; 53: 1295–6. 2. Bean D, Wareham D. Paradoxical effect of 1-(1-naphthylmethyl)piperazine on resistance to tetracyclines in multidrug-resistant Acinetoba...

OBJECTIVE Acinetobacter baumannii species cause nosocomial infections and can subsequently develop multidrug resistance (MDR). The objective of this study was to evaluate the susceptibility of A. baumannii to a novel combination of colistin and tigecycline, which may provide a faster and more efficacious treatment via a synergistic effect. METHODS We included 50 MDR A. baumannii samples that ...

A newly formulated colistin sulphate solution was prepared in a previous study as a potential agent for intramuscular injection and its effectiveness, toxicity and pharmacokinetics were investigated. In order to provide more information to establish scientific guidance for safe use of this preparation, its residue depletion in swine tissues following intramuscular administration was investigate...