The present study was performed to investigate the effects of long-term intraperitoneal (IP) injection of vitamin B12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. Neuropathic pain was induced by crush injury in right tibial nerve. Acetone spray and von Frey tests were used to obtain cold and mechanical allody...

Domestication can be defined as the artificial selection in animals to achieve morphological, physiological, and developmental conformity human needs, with aim of improving various limitations species under a feeding environment. The future sustainability aquaculture may rely partly on availability numerous domesticated fish species. However, underlying adaptive mechanisms that result domestica...

BACKGROUND Calcitonin gene-related peptide-α (CGRPα) is a classic marker of peptidergic nociceptive neurons and is expressed in myelinated and unmyelinated dorsal root ganglia (DRG) neurons. Recently, we found that ablation of Cgrpα-expressing sensory neurons reduced noxious heat sensitivity and enhanced sensitivity to cold stimuli in mice. These studies suggested that the enhanced cold respons...

frost tolerance of winter wheat depends primarily on a strong vernalization requirement, delaying the transition to reproductive phase. the responses of four bread wheat cultivars (triticum aestivum l.) to low-temperatures were examined in controlled environment and field conditions. prolonged cold treatment accelerated the transition to reproductive development in winter wheats (cv. norstar an...