objective(s):previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (stz)-induced diabetic rats. recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. howev...

BACKGROUND Cognitive deficits are a core feature of early schizophrenia. However, the pathological foundations underlying cognitive deficits are still unknown. The present study examined the association between gray matter density and cognitive deficits in first-episode schizophrenia. METHOD Structural magnetic resonance imaging of the brain was performed in 34 first-episode schizophrenia pat...

Cognitive deficits in major depressive disorder (MDD) patients have been described in numerous studies. However, few reports have aimed to describe cognitive deficits in the remitted state of MDD and the mediational effect of cognitive deficits on occupational outcome. The aim of the current review is to synthesize the literature on the mediating and moderating effects of specific domains of co...

Inflammatory processes play a critical role in the pathogenesis of the neurodegenerative disorders and are associated with cognitive impairments. Nonsteroidal anti-inflammatory drugs (NSAIDs) and nitric oxide releasing NSAIDs are reported to be effective in reducing the risk of developing AD or cognitive impairments. Present experiments were performed to study the possible effect of nitro napro...