INTRODUCTION Age-associated cognitive decline-or normal (non-pathological, normative, usual) cognitive ageing-is an important human experience which differs in extent between individuals. The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences. AREAS OF AGREEM...

Stroke and cognitive impairment are common among older persons.1 It is estimated that the lifetime risk for stroke is approximately 1 in 5 for women and 1 in 6 for men,2 and almost one-third of persons with stroke, which typically may involve motor, sensory, or other deficits, may have a significant degree of cognitive impairment within several months of the event.1 Furthermore, silent strokes ...

BACKGROUND AND PURPOSE In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline. METHODS We included 334 patients with subjective cognitive decline. Follow-up was 3±2 years. RESULTS Fifty-three (16%) patients progressed clinically to mild cognitive impairment or dementia. White matter hyperintensit...

OBJECTIVE Cognitive reserve is associated with a lower risk of dementia, but the extent to which it shapes cognitive aging trajectories remains unclear. Our objective is to examine the impact of 3 markers of reserve from different points in the life course on cognitive function and decline in late adulthood. METHODS Data are from 5,234 men and 2,220 women, mean age 56 years (standard deviatio...

Persons with subjective cognitive decline are reported to experience a decline in cognitive capacity without measurable cognitive deficits on objective testing.1 In a meta-analysis, subjective cognitive decline was present in about 17% of healthy elderly.2 The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years before the diagnosis of AD dementia.3 Subjective c...