Non-random usage of synonymous codons, known as “codon bias”, has been described in many organisms, from bacteria to Drosophila, but little is about it phytoplankton. This phenomenon thought be driven by selection for translational efficiency. As the efficacy proportional effective population size, species with large sizes, such phytoplankton, are expected have strong codon bias. To test this, ...

abstract   background: the polymorphic variants at codon 72 of the p53 gene, encoding either proline or arginine at residue 72, produce marked change in the structure of p53. from the evidence that the dnamismatch repair system and p53 interact to maintain genomic integrity, we hypothesized that the codon 72 variation may influence the prevalence of microsatellite instability a feature of malig...

Beta thalassemia is the  most common autosomal recessive disorder. The present study reports a rare β globin gene mutation, HBB: c.180G>A: codon 59 (AAG/AAA), in a patient from Gilan province, northern Iran. Nucleotide sequencing of amplified DNA belonging to a 35 years old man presenting mild hypochromia revealed a synonymous mutation due to a G>A conversion at the third position of codon 59 o...

P53 is one of the gene that has important role in human cell cycle and in the human cancers too.Models of codon substitution make it possible to separate mutational biases in the DNA fromselective constraints on the protein, and offer a great advantage over amino acid models forunderstanding the evolutionary process of proteins and protein-coding DNA sequences. In thiswork, we investigated abou...