This study was conducted to elucidate the effect of pH on the toxicity of cadmium, cobalt and copper to the green alga Scenedesmus bijuga. The results revealed that the growth of Scenedesmus bijuga increased with increasing pH. However, the accumulation, the accumulation factor and the amount of free ionic forms of each metal decreased. Generally, it appears that the metals tested exert more to...

Occupational and environmental exposure to Co and Cr has been previously linked to a wide array of inflammatory and degenerative conditions and cancer. Recently, significant health concerns have been raised by the high levels of Cr and Co ions and corrosion products released by biomedical implants. Herein, we set to analyze the biological responses associated with Co and Cr toxicity. Histologic...

UNLABELLED Metal-on-metal (MoM) hip arthroplasties comprised of cobalt and chromium alloys continue to be successful alternatives to conventional bearings in younger patients with osteoarthritis (OA). A small proportion of patients have unusually high levels of cobalt and chromium ions postoperatively. Given the increasing prevalence of MoM bearings and the potential for cellular toxicity, the ...

BACKGROUND AND PURPOSE Metal ion toxicity both locally and systemically following MoM hip replacements remains a concern. Cobalt ions have been shown to induce secretion of proinflammatory chemokines locally; however, little is known about their effect systemically. We investigated the in vitro effect of cobalt ions on a variety of cell lines by measuring production of the proinflammatory chemo...

Skin absorption and toxicity on keratinocytes of cobalt oxide nanoparticles (Co3O4NPs) have been investigated. Co3O4NPs are commonly used in industrial products and biomedicine. There is evidence that these nanoparticles can cause membrane damage and genotoxicity in vitro, but no data are available on their skin absorption and cytotoxicity on keratinocytes. Two independent 24 h in vitro experim...

The mold Neurospora crassa does not accumulate porphyrins in iron deficiency but instead accumulates the sideramine desferricoprogen. In iron deficiency there is an accumulation of &aminolevulinic acid and the d-aminolevulinic acid dehydratase level is very low. A similar situation exists in cobalt toxicity and zinc deficiency. The b-aminolevulinic acid synthetase and ferroprotoporphyrin chelat...

Bleomycin is widely used for treating several types of human tumors as well as a variety of experimental tumors. The ability of this antibiotic to bind and to damage DNA has been proposed to be responsible for its antitumor effect. Bleomycin is also a good chelator for several metals, e.g., iron, copper, and others. Bleomycin:metal complexes have been investigated in detail particularly for the...