نتایج جستجو برای: coagulation pathway

تعداد نتایج: 358621  

Journal: :Blood 2017
Yuichi Kamikubo G Loredana Mendolicchio Antonella Zampolli Patrizia Marchese Andrea S Rothmeier Jennifer Nagrampa Orje Andrew J Gale Sriram Krishnaswamy András Gruber Henrik Østergaard Lars C Petersen Wolfram Ruf Zaverio M Ruggeri

Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation initiation complex can selectively activate the antihemophilic cofactor, FVIII, triggering the hemostatic intrinsic coagulation pathway independently of thrombin feedback loops...

2015
Yi Wu

The contact system, also named as plasma kallikrein-kinin system, consists of three serine proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and the nonenzymatic cofactor high molecular weight kininogen (HK). This system has been investigated actively for more than 50 years. The components of this system and their interactions have been elucidated from in ...

Journal: :Circulation 1999
T Pernerstorfer U Hollenstein J Hansen M Knechtelsdorfer P Stohlawetz W Graninger H G Eichler W Speiser B Jilma

BACKGROUND Lipopolysaccharide (LPS) is a major trigger of sepsis-induced disseminated intravascular coagulation (DIC) via the tissue factor (TF)/factor VIIa-dependent pathway of coagulation. Experimental endotoxemia has been used repeatedly to explore this complex pathophysiology, but little is known about the effects of clinically used anticoagulants in this setting. Therefore, we compared wit...

2006
Elena Haapaniemi Turgut Tatlisumak Markku Kaste Riitta Lassila Juhani Sivenius

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Review of the literature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Ischemi...

2011
Emily K. Waters Ryan M. Genga Michael C. Schwartz Jennifer A. Nelson Robert G. Schaub Karen A. Olson Jeffrey C. Kurz Kathleen E. McGinness

Hemophilia A and B are caused by deficiencies in coagulation factor VIII (FVIII) and factor IX, respectively, resulting in deficient blood coagulation via the intrinsic pathway. The extrinsic coagulation pathway, mediated by factor VIIa and tissue factor (TF), remains intact but is negatively regulated by tissue factor pathway inhibitor (TFPI), which inhibits both factor VIIa and its product, f...

Journal: :Blood 2011
Emily K Waters Ryan M Genga Michael C Schwartz Jennifer A Nelson Robert G Schaub Karen A Olson Jeffrey C Kurz Kathleen E McGinness

Hemophilia A and B are caused by deficiencies in coagulation factor VIII (FVIII) and factor IX, respectively, resulting in deficient blood coagulation via the intrinsic pathway. The extrinsic coagulation pathway, mediated by factor VIIa and tissue factor (TF), remains intact but is negatively regulated by tissue factor pathway inhibitor (TFPI), which inhibits both factor VIIa and its product, f...

2015
Vladimir N. Kolyadko Sofya V. Lushchekina Tatiana A. Vuimo Stepan S. Surov Ruzanna A. Ovsepyan Vera A. Korneeva Ivan I. Vorobiev Nadezhda A. Orlova Leonid Minakhin Konstantin Kuznedelov Konstantin V. Severinov Fazoil I. Ataullakhanov Mikhail A. Panteleev Eugene A. Permyakov

Factor XIIa (fXIIa) is a serine protease that triggers the coagulation contact pathway and plays a role in thrombosis. Because it interferes with coagulation testing, the need to inhibit fXIIa exists in many cases. Infestin-4 (Inf4) is a Kazal-type inhibitor of fXIIa. Its specificity for fXIIa can be enhanced by point mutations in the protease-binding loop. We attempted to adapt Inf4 for the se...

Journal: :Hepatology 2006
Stephen H Caldwell Maureane Hoffman Ton Lisman B Gail Macik Patrick G Northup K Rajender Reddy Armando Tripodi Arun J Sanyal

Normal coagulation has classically been conceptualized as a Y-shaped pathway, with distinct "intrinsic" and "extrinsic" components initiated by factor XII or factor VIIa/tissue factor, respectively, and converging in a "common" pathway at the level of the FXa/FVa (prothrombinase) complex. Until recently, the lack of an established alternative concept of hemostasis has meant that most physicians...

Journal: :Journal of Biochemical Technology 2022

Covid-19 is a severe acute respiratory syndrome, the disease presents with ranging from asymptomatic to symptomatic illness multiple organ failure and death, can cause effect on coagulation system. This study aimed determine of covid 19 extrinsic intrinsic pathway [prothrombin time(PT), international normalized ratio (INR), activated partial thromboplastin time (APTT)] association age gende

2012
Gabriele Demetz Ilka Ott

The intimate connection between coagulation and inflammation in the pathogenesis of vascular disease has moved more and more into focus of clinical research. This paper focuses on the essential components of this interplay in the settings of cardiovascular disease and acute coronary syndrome. Tissue factor, the main initiator of the extrinsic coagulation pathway, plays a central role via causin...

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