The clotting process is a dynamic array of multiple processes which can be described in four phases: platelet plug initiation and formation, clotting process propagation by the coagulation cascade, clotting termination by antithrombotic mechanisms and clot removal by fibrinolysis. The liver plays a central role in each of these phases of clotting process, as it synthesizes the majority of coagu...

Haematological variables in patients with eosinophilia and in healthy control subjects were studied in order to determine whether there were abnormalities in the coagulation system in patients. We found significantly elevated levels of fibrinogen, fibrin degradation products, platelet number and Pthromboglobulin in patients. The abnormalities were not related to the causes of eosinophilia nor t...

C OMPLEX ALTERATION of blood coagulation occurs in the course of a number of systemic disorders. In contrast to the congenital defects of hemnostasis which are usually characterized by a single clotting factor deficiency, the changes which may accompany acquired disease are characteristicallv multiple. These multiple defects tend to form typical patterns which reflect the physiologic abnormalit...

Abnormalities of hemostasis and malignancy have been recognized since the 19th century. Thrombosis and hypercoagulability are reported in as many as 60 percent of patients with malignancies. Decreased levels of protein coagulation factors, circulating anticoagulants and platelet numbers, and function changes are reported. The purpose of this work is to report a case of portal thrombosis in a pa...

Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for a deranged coagulation in critically ill patients and each of these underlying disorders may require specific therapeutic or supportive management. In recent years, n...

background: type 2 diabetic mellitus patients are amongst the most susceptible groups to vascular abnormalities, which predominantly lead to myocardial disease. the hypercoagulable state has been widely studied by researchers as being the major suspicious mechanism facilitating the consecutive chain of molecular events leading to these complications. however, there is no consensus on the defini...

We prospectively analyzed the coagulation abnormalities in 111 children with Celiac disease at diagnosis and its association with histology grade on duodenal biopsy; 27% had deranged prothrombin time. There was an increasing proportion of coagulopathy with progression of Marsh Grade on duodenal histology.

We thank Drs Shahar, McGovern, and Spraflca for their interest in our paper in which we demonstrated, inter alia, that low doses of aspirin may not be as efficacious as higher doses. Our sample population was indeed matched, and Shahar et al are correct in pointing out that analysis for data obtained according to a matched design should have been performed. However, it is possible to ignore mat...

We thank Drs Shahar, McGovern, and Spraflca for their interest in our paper in which we demonstrated, inter alia, that low doses of aspirin may not be as efficacious as higher doses. Our sample population was indeed matched, and Shahar et al are correct in pointing out that analysis for data obtained according to a matched design should have been performed. However, it is possible to ignore mat...