نتایج جستجو برای: coa synthase

تعداد نتایج: 106351  

2001
W. DOUGLAS KENNETH D. CLINKENBEARD

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase has been purified to homogeneity from avian liver. The enzyme in dilute phosphate buffer, pH 7.0, has an szolu, of 5.7 S and a molecular weight of 105,000 determined by sedimentation equilibrium; the presence of 0.1 M KC1 causes dissocation to a form one-half that size, i.e. about 57,000 daltons. Since the subunit molecular weight of the syn...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1987
G Gil J R Smith J L Goldstein M S Brown

3-Hydroxy-3-methylglutaryl coenzyme A synthase (hydroxymethylglutaryl-CoA synthase, EC 4.1.3.5) is a negatively regulated enzyme in the synthetic pathway for cholesterol, isopentenyl tRNA, and other isoprenoids. The 5'-untranslated region of the mRNA for Chinese hamster hydroxymethylglutaryl-CoA synthase contains an optional exon of 59 nucleotides located 10 nucleotides upstream of the translat...

Journal: :Journal of Biological Chemistry 2000

Journal: :Journal of animal science 2002
M A Lane R L Baldwin B W Jesse

Ketogenesis is the conversion of acetyl-CoA to the ketone bodies acetoacetate and beta-hydroxybutyrate (BHBA). In hepatic ketogenesis, which occurs during fasting in both nonruminant and ruminant animals, the source of acetyl-CoA is the mitochondrial oxidation of predominantly long-chain fatty acids. In the mature, fed ruminant animal, the ruminal epithelium is also capable of producing ketone ...

2005
RICHARD G. HANSFORD

(1) A 'cycling' method involving citrate synthase (EC 4.1.3.7) and malate dehydrogenase (EC 1.1.1.37) was modified by the inclusion of succinyl-CoA synthetase (EC 6.2.1.5) and hexokinase (EC 2.7.1.1) to permit the determination of very small amounts of succinyl-CoA in addition to CoA and acetyl-CoA. (2) Application of this technique to blowfly (Phormia regina) flight-muscle extracts reveals no ...

Journal: :The Journal of biological chemistry 1977
R E Reeves L G Warren B Susskind H S Lo

Under anaerobic conditions, cells of Entamoeba histolytica grown with bacteria produce H2 and acetate while cells grown axenically produce neither. Aerobically, acetate is produced and O2 is consumed by amebae from either type of cells. Centrifuged extracts, 2.4 x 106 x g x min, from both types of cells contain pyruvate synthase (EC 1.2.7.1) and an acetate thiokinase which, together, form a sys...

Journal: :GSC biological and pharmaceutical sciences 2022

Hyperlipidemia refers to elevated levels of lipids and cholesterol in the blood. It plays an important role development atherosclerosis, main cause death world. Medicinal plants can lower blood by many mechanisms included inhibition expression fatty acid synthase, decreasing free release, HMG-CoA reductase, increasing fecal excretion fat cholesterol, activity pancreatic lipase absorption. The c...

Journal: :Journal of bacteriology 1965
W S Wegener H C Reeves S J Ajl

Wegener, Warner S. (Albert Einstein Medical Center, Philadelphia, Pa.), Henry C. Reeves, and Samuel J. Ajl. Heterogeneity of the glyoxylate-condensing enzymes. J. Bacteriol. 90:594-598. 1965.-Evidence is presented that the enzymatic condensations of glyoxylate with acetyl-CoA (malate synthase), propionyl-CoA (alpha-hydroxyglutarate synthase), butyryl-CoA (beta-ethylmalate synthase), and valeryl...

Journal: :Journal of lipid research 1992
J A Cuthbert P E Lipsky

The ability of mitogenic stimulation of human T lymphocytes to alter the expression of genes involved in sterol metabolism was examined. Messenger RNA levels for 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, HMG-CoA synthase, and low density lipoprotein (LDL) receptor were quantified in resting and mitogen-stimulated T lymphocytes by nuclease protection assay. Mitogenic stimulation...

Journal: :Journal of bacteriology 2013
John C VanNice D Andrew Skaff Gerald J Wyckoff Henry M Miziorko

Enzymes of the isoprenoid biosynthetic pathway in halophilic archaea remain poorly characterized, and parts of the pathway remain cryptic. This situation may be explained, in part, by the difficulty of expressing active, functional recombinant forms of these enzymes. The use of newly available expression plasmids and hosts has allowed the expression and isolation of catalytically active Halofer...

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