Natural medicines have attracted wide attention in recent years. It is of great significance to clarify the pharmacological mechanisms of natural medicines. In prior studies, we established a method for elucidating pharmacological mechanisms of natural products contained in connectivity map (cMap), in terms of module profiles of gene expression in chemical treatments. In this study, we explore ...

Nerve function assessments are crucial for surgical intervention during acoustic neuroma surgery. Cranial nerves such as acoustic and facial nerves, can be possibly damaged during tumor dissection. Proper surgical intervention should prevent neurological deficit and achieve total tumor removal. Conventionally, nerve function is qualitatively evaluated by surgeon and neurologist. Facial nerves c...

We report the case of a right-handed 67-year-old uremic woman with severe left carpal tunnel syndrome (CTS) in whom preoperative neurophysiologic data suggested that the thenar motor branch (TMB) of the median nerve ran an anomalous course that was confirmed during surgical release. The patient had undergone periodic hemodialysis for 10 years through a vascular graft at the left forearm. The pa...

Purpose: To investigate the impact of shoulder subluxation (SS) on peripheral nerve conduction and function hemiplegic upper extremity (HUE) in poststroke patients.Methods: Thirty post-stroke patients were selected (SS group: 15 patients, non-SS respectively). Evaluation limbs: compound muscle action potential (CMAP) amplitude latency suprascapular, axillary, musculocutaneous, radial, median, u...

Gene-set-based analysis (GSA), which uses the relative importance of functional gene-sets, or molecular signatures, as units for analysis of genome-wide gene expression data, has exhibited major advantages with respect to greater accuracy, robustness, and biological relevance, over individual gene analysis (IGA), which uses log-ratios of individual genes for analysis. Yet IGA remains the domina...

BACKGROUND Electromyography-guided phrenic nerve (PN) monitoring using a catheter positioned in a hepatic vein can aid in preventing phrenic nerve palsy (PNP) during cryoballoon ablation for atrial fibrillation. We wanted to evaluate the feasibility and efficacy of PN monitoring during procedures using second-generation cryoballoons. METHODS AND RESULTS This study included 140 patients (43 wo...

Compound muscle action potential (CMAP) and motor unit number estimation (MUNE) are electrophysiological techniques that can be used to monitor the functional status of a motor unit pool in vivo. These measures can provide insight into the normal development and degeneration of the neuromuscular system. These measures have clear translational potential because they are routinely applied in diag...

This paper presents the design, implementation, and experimental evaluation of CMAP (Conflict Maps), a system that increases the number of successful concurrent transmissions in a wireless network, achieving higher aggregate throughput compared to networks that use carrier sense multiple access (CSMA). CMAP correctly identifies and exploits exposed terminals in which two senders are within rang...

Folding simulations on peptides and proteins using empirical force fields have demonstrated the sensitivity of the results to details of the backbone potential. A recently revised version of the additive CHARMM protein force field, which includes optimization of the backbone CMAP potential to achieve good balance between different types of secondary structure, correcting the α-helical bias pres...

In this paper, we propose a novel method based on the second-order conditional maximum a posteriori (CMAP) to improve the performance of the global soft decision in speech enhancement. The conventional global soft decision scheme is found through investigation to have a disadvantage in that the global speech absence probability (GSAP) in that scheme is adjusted by a fixed parameter, which could...