BACKGROUND: Clostridium septicum has played a significant role as a causative agent of many acute fetal diseases in man and animals. Alpha- toxin is the main factor in the pathogenesis of C. septicum with hemolytic, necrotic and lethal activities. OBJECTIVES: The study was designed to evaluate alpha-toxin purification and antibody production rate against a local strain of C. septicum NH2 which ...

clostridium septicum a gram positive anaerobic bacterium produces several toxins including alpha, beta, gamma and delta. c. septicum alpha toxin is lethal and is responsible for a serious disease known as gas gangrene. the aim of the present study was to molecular cloning and sequencing of c. septicum vaccine strain alpha toxin gene. genomic dna was extracted using standard phenol and chlorofor...

CT findings (figures 1 and 2) were consistent with infection of a liver metastasis as a result of gas-producing bacteria. Culture specimens grew C. septicum. The patient died 28 h after onset of symptoms despite intensive medical treatment. Clostridium species are anaerobic, gram-positive, spore-forming bacteria. Clostridial infections are believed to be more prevalent among patients with malig...

A 90-year-old female was admitted with a probable adverse reaction to codeine phosphate after a 10-day history of lethargy, abdominal pain and increased colostomy output. A recent staging CT thorax/abdomen/pelvis showed a recurrence of a previous colon cancer with lung metastasis. She was pyrexial, but initial clinical examination was unremarkable. Sixteen hours later, she deteriorated and deve...