Postoperative administration of clonidine is an effective treatment for shivering. However, the ability of this drug to stop postanesthetic shivering when administered intraoperatively remains controversial. Furthermore, the relative efficacy of clonidine during isoflurane and propofol anesthesia remains unknown. We therefore evaluated the incidence of postanesthetic shivering in patients given...

As various fullerene derivatives have been developed, it is necessary to explore their photophysical properties for potential use in photoelectronics and medicine. Here, we address the photophysical properties of newly synthesized water-soluble fullerene-based nanoparticles and polyhydroxylated fullerene as a representative water-soluble fullerene derivative. They show broad emission band arisi...

The interactions of compound ZDM-81 with some CNS neurotransmitter systems were studied using in vivo methods to evaluate the interaction dopaminergic (catalepsy, induced haloperidol), adrenergic (clonidine hypothermia), GABAergic (test flumazenil) and serotonergic (5-hydroxytryptophan hyperkinesis) systems. It was shown that is able prolong potentiate effects 5-hydroxytryptophan, reduces catal...

A highly-ordered 3D covalent fullerene framework is presented with a structure based on octahedrally functionalized fullerene building blocks in which every fullerene is separated from the next by six functional groups and whose mesoporosity is controlled by cooperative self-assembly with a liquid-crystalline block copolymer. The new fullerene-framework material was obtained in the form of supp...

BACKGROUND AND OBJECTIVES Clinical effects and the potential synergism between clonidine, an alpha2-adrenergic agonist, and ropivacaine have not been studied in patients undergoing epidural anesthesia. This research aimed at clinically evaluating clonidine associated to ropivacaine for epidural anesthesia. METHODS Participated in this double-blind study 60 patients of both genders who were di...

The rostral ventrolateral medulla (RVLM) may play an important role in the sympatholytic and hypotensive effects of clonidine. The present study examined which type of presympathetic RVLM neuron is inhibited by clonidine, and whether the adrenergic presympathetic RVLM neurons are essential for clonidine-induced sympathoinhibition. In chloralose-anesthetized and ventilated rats, clonidine (10 mi...

Postoperative administration of clonidine is an effective treatment for shivering. However, the ability of this drug to stop postanesthetic shivering when administered intraoperatively remains controversial. Furthermore, the relative efficacy of clonidine during isoflurane and propofol anesthesia remains unknown. We therefore evaluated the incidence of postanestbetic shivering in patients given...

Background. Dextromethorphan is a noncompetitive N-methyl D-aspartate receptor antagonist that is clinically feasible for relieving the opioid withdrawal symptoms. This study compares the efficacy of a combination therapy with dextromethorphan and clonidine to treatment with clonidine alone. Methods and Materials. In this double-blind randomized clinical trial, patients were selected from inpat...

A fullerene graph is a planar cubic graph whose all faces are pentagonal and hexagonal. The structure of cyclic edge-cuts of fullerene graphs of sizes up to 6 is known. In the paper we study cyclic 7-edge connectivity of fullerene graphs, distinguishing between degenerated and non-degenerated cyclic edge-cuts, regarding the arrangement of the 12 pentagons. We prove that if there exists a non-de...