The objective of the current study was to develop a validated, specific stability-indicating reversed-phase liquid chromatographic (LC) method for the quantitative determination of escitalopram oxalate and clonazepam and their related substances in bulk drugs and pharmaceutical dosage forms in the presence of degradation products. Forced degradation studies were performed on the pure drugs of e...

Clonazepam associated hypothyroidism: Aforethought on a concealed dilemmaRupam Gill,Dipanjan Bhattacharjee,Navin A. Patil,Shripathy M. Bhat

We carried out a retrospective survey of 25 years of clinical experience with the use of clonazepam as a vestibular and tinnitus suppressant in the pharmacological treatment of vestibular or cochleovestibular disorders due to different causes. We reviewed the medical records of 3,357 outpatients treated with a 0.5 or 1.0-mg daily dosage of oral clonazepam during 60-180 days. Complete or substan...

objectives juvenile myoclonic epilepsy(j.m.e.) needs life-long anti-epileptic drug (aed) treatment. of various drugs tried in this condition, valproate effectively treats all types of seizures seen in j.m.e. among valproate side effects, neural tube defects (ntd) in the offspring, is a deterring factor in its use in childbearing period. to avoid ntd, most authorities advise on switching to aed ...

We present an infant girl with hyperekplexia, hypertonia, hyperreflexia and a characteristic exaggerated response to nose tap. This disorder is important to recognize because of the increased risk of apnea and sudden infant death, This infant responded to clonazepam.

Two types of benzodiazepine binding sites for [3H]diazepam in mammalian central nervous tissue were identified using selective in vitro tissue culture and in situ kainic acid lesion techniques. These two binding sites were pharmacologically distinguished by differential displacement of the [3H]diazepam radioligand using the centrally active benzodiazepine, clonazepam, and the centrally inactive...

BACKGROUND The present study aimed at investigating in healthy volunteers the effects of diazepam and clonazepam on beta-cell function, insulin sensitivity and glucose effectiveness based on the frequently sampled intravenous (0.5 gkg-1) glucose tolerance test with minimal-model analysis. METHODS The study was designed as a double-blind, placebo-controlled, cross-over clinical trial. Diazepam...