BACKGROUND Single interventions in chronic fatigue syndrome have shown only limited effectiveness, with few studies of comprehensive treatment programmes. AIMS To examine the effect of a comprehensive cognitive-behavioural treatment (CCBT) programme compared with placebo-controlled mirtazapine medication in patients with chronic fatigue, and to study the effect of combined medication and CCBT...

BACKGROUND This randomized, placebo-controlled, double-blind pilot study evaluated the impact of repetitive transcranial magnetic stimulation (rTMS) on clinical, cognitive, and social performance in women suffering with postpartum depression. METHODS Fourteen patients were randomized to receive 20 sessions of sham rTMS or active 5 Hz rTMS over the left dorsolateral prefrontal cortex. Psychiat...

objective: major depressive disorder is a severe disorder that has a significant impact on the psychological and social functioning of children and adolescents. considering current limitations in the treatment of this disorder, the present study was performed to evaluate the efficacy of fluvoxamine in the treatment of children and adolescents with major depressive disorder. method: in an open t...

some previous studies have reported that adhd is often comorbid with anxiety disorders. the aim of the present study was to evaluate the effectiveness of reboxetine in treating outpatient children and adolescents with adhd and comorbid anxiety disorders.in this open-label study, 25 outpatient children and adolescents, aged 6-16 years were selected by convenient sampling and underwent treatment ...

Background: In patients with Alzheimer’s disease, global assessment scales, such as the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Clinician’s Interview-Based Impression Plus Caregiver Input (CIBI plus), and Global (CGI) are commonly used. Objective: To clinically understand interpret associations between these we examined linkages for total change scores CDR-SB, CIBI plus, CGI. Methods: I...

Background: In patients with Alzheimer’s disease, global assessment scales, such as the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Clinician’s Interview-Based Impression Plus Caregiver Input (CIBI plus), and Global (CGI) are commonly used. Objective: To clinically understand interpret associations between these we examined linkages for total change scores CDR-SB, CIBI plus, CGI. Methods: I...

BACKGROUND The clinical Global Impression Scale (CGI) is commonly used as a primary outcome measure in studies evaluating the efficacy of treatments for anxiety disorders. The current study evaluated the psychometric properties and predictors of clinicians' ratings on an adapted version of the CGI among individuals with social anxiety disorders. METHOD An independent assessor administered the...

BACKGROUND Since its first publication, the Clinical Global Impression Scale (CGI) has become one of the most widely used assessment instruments in psychiatry. Although some conflicting data has been presented, studies investigating the CGI's validity have only rarely been conducted so far. It is unclear whether the improvement index CGI-I or a difference score of the severity index CGI-S (dif)...