testicular cancer typically spreads to the lymph nodes, but hematogenous dissemination to distant organs can also occur. bone metastasis is uncommon and is thought to be a poor prognostic indicator. jaw metastasis is exceedingly rare but is of great clinical significance, since it may be the first sign of an occult testicular cancer or the first evidence of relapse of a known tumor. herein, we ...

Clear cells can be found in numerous salivary and non-salivary tumors in the head and neck region, including metastatic lesions. They are rare low-grade tumors accounting for less than 1% of all salivary gland tumors and occur almost exclusively in the intra-oral minor salivary glands. Hyalinizing clear cell carcinoma (HCCC) is an extremely rare and recently described neoplasm predominantly aff...

To investigate the effects of the two-pore-domain potassium (K2P) channel TASK-3 in a syngeneic murine model for malignant glioma. Malignant or high-grade glioma (WHO grade III and IV) are the most common and most aggressive primary brain tumors in adults. Despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. However, recent phase I and II trials hav...

The image recognotion and the classification of objects according to the images are more in focus of interests, especially in medicine. A mathematical procedure allows us, not only to evaluate the amount of data per se, but also ensures that each image is pro- cessed similarly. Here in this study, we propose the power of shape analysis, in conjunction with neural networks for reducing white n...

Water clear cells; they can be seen in many tumors such as germ cell tumors, kidney lymphomas, sarcomas, thymic carcinomas, parathyroid paraganglioma. They may primary or occur a result of metastatic conditions. Therefore, histopathologically differential diagnosis difficult confusing. Clinical findings, radiological findings and histopathological evaluation required for diagnosis. 
 Here,...

Oral cavity metastatic tumors derived from primary other corporal regions are rare, representing barely 1 % of all malignant tumors. Differential diagnosis these lesions is challenging due to the wide spectrum with similar clinical presentation and especially when presence a tumor goes undetected. We present case 55-year-old male painless in anterior maxillary region, vestibular gingiva palate,...

PURPOSE The purpose of the present work was to investigate the relationship between mRNA expression of ERCC1 and XPB, two key genes in the nucleotide excision repair pathway, and clinical resistance of platinum-chemotherapy in histological subtypes of epithelial ovarian cancer. EXPERIMENTAL DESIGN mRNA levels of ERCC1 and XPB in epithelial ovarian cancer specimens from 126 different individua...

The coiled and dotted vessels in a serpiginous arrangement or "string of pearls" is considered a classical vascular pattern associated with clear cell acanthoma. We present three cases of epidermal tumors different from clear cell acanthoma that have the same "string of pearls" vascular pattern. Even though most authors keep considering the "string of pearls" vascular pattern an almost pathogno...

Renal cell carcinoma (RCC) comprises 2-3% of all malignancies. Approximately 90% of renal tumors are RCCs, and 15% of these are non-clear cell tumors, which include papillary, chromophobe, Bellini duct (collecting duct) and sarcomatoid tumors. Antiangiogenic agents (sorafenib, sunitinib, pazopanib, temsirolimus, or bevacizumab), have not been specifically evaluated in phase III trials in patien...