Cell states in hematopoiesis are controlled by master regulators and by complex circuits of a growing family of RNA species impacting cell phenotype maintenance and plasticity. Circular RNAs (circRNAs) are rapidly gaining the status of particularly stable transcriptome members with distinctive qualities. RNA-seq identified thousands of circRNAs with developmental stage- and tissue-specific expr...

The expression patterns of endogenous circular RNA (circRNA) molecules during epidermal stem cell (EpSC) differentiation have not previously been explored. Here, we show that circRNAs are abundantly expressed in EpSCs and that their expression change dramatically during differentiation in a coordinated manner. Overall, circRNAs are expressed at higher levels in the differentiated cells, and man...

Circular RNA (circRNA) is a kind of novel endogenous noncoding formed through back-splicing mRNA precursor. The biogenesis, degradation, nucleus–cytoplasm transport, location, and even translation circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development di...

Ovarian tumour therapy has been known to cause ovary ageing. The competitive endogenous RNA (ceRNA) network plays an indispensable role in various diseases. We constructed the ceRNA examine of circular (circRNA) ovaries older women and elucidate intervention mechanism Ziyin Buyang Formula. tissue datasets were obtained from Gene Expression Omnibus (GEO) database screened for differentially expr...

In this study, we will explore the expression profile of circular RNA (cRNA) in gastric cancer tissues and plasma order to evaluate its potential as a molecular marker for detection cancer. Additionally, research cRNA normal tissue. Reverse transcription drop digital polymerase chain reaction (RT ddPCR), circRNA profiling, prediction circRNA-microRNA interactions, design method RT ddPCR, well a...

Objective: To explore the mechanism of circRNA-vgll3 in osteogenic differentiation human bone marrow mesenchymal stem cells. Methods: BMSCs cells were transfected with circRNA-vgll3, and divided into high-level group, low-level negative control group (circRNA-vgll3 not transfected) according to amount transfection. The proliferation apoptosis osteoblasts each analyzed, alkaline phosphatase (ALP...

Our understanding of the highly specialized functions for small non-coding single-stranded RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to evolve. Circular RNAs (circRNAs), a recently discovered class of ssRNA enriched in the brain and retina, are extremely stable and intrinsically resilient to degradation by exonuclease. Conventional methods of ssRNA, mi...

Motivation Circular RNAs (circRNAs) are a class of non-coding RNAs that are widely expressed in various cell lines and tissues of many organisms. Although the exact function of many circRNAs is largely unknown, the cell type-and tissue-specific circRNA expression has implicated their crucial functions in many biological processes. Hence, the quantification of circRNA expression from high-throug...