نتایج جستجو برای: circadian type

تعداد نتایج: 1364492  

2012
Elizabeth F. Stone Ben O. Fulton Janelle S. Ayres Linh N. Pham Junaid Ziauddin Mimi M. Shirasu-Hiza

Survival of bacterial infection is the result of complex host-pathogen interactions. An often-overlooked aspect of these interactions is the circadian state of the host. Previously, we demonstrated that Drosophila mutants lacking the circadian regulatory proteins Timeless (Tim) and Period (Per) are sensitive to infection by S. pneumoniae. Sensitivity to infection can be mediated either by chang...

2012
M. Ann Kelly Simon D. Rees M. Zafar I. Hydrie A. Samad Shera Srikanth Bellary J. Paul O’Hare Sudhesh Kumar Shahrad Taheri Abdul Basit Anthony H. Barnett

BACKGROUND Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variant...

Journal: :Chronobiology international 2011
David J Durgan Ju-Yun Tsai Maximiliano H Grenett Betty M Pat William F Ratcliffe Carolina Villegas-Montoya Merissa E Garvey Jeevan Nagendran Jason R B Dyck Molly S Bray Karen L Gamble Jeffrey M Gimble Martin E Young

Circadian dyssynchrony of an organism (at the whole-body level) with its environment, either through light-dark (LD) cycle or genetic manipulation of clock genes, augments various cardiometabolic diseases. The cardiomyocyte circadian clock has recently been shown to influence multiple myocardial processes, ranging from transcriptional regulation and energy metabolism to contractile function. Th...

2015
Jelena Kusakina Zoe Rutterford Sean Cotter María C. Martí David A. Laurie Andy J. Greenland Anthony Hall Alex A. R. Webb David E. Somers

Circadian clocks regulate many aspects of plant physiology and development that contribute to essential agronomic traits. Circadian clocks contain transcriptional feedback loops that are thought to generate circadian timing. There is considerable similarity in the genes that comprise the transcriptional and translational feedback loops of the circadian clock in the plant Kingdom. Functional cha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Victoria Y Gorbacheva Roman V Kondratov Renliang Zhang Srujana Cherukuri Andrei V Gudkov Joseph S Takahashi Marina P Antoch

The circadian clock controls many aspects of mammalian physiology, including responses to cancer therapy. We find that wild-type and circadian mutant mice demonstrate striking differences in their response to the anticancer drug cyclophosphamide (CY). While the sensitivity of wild-type mice varies greatly, depending on the time of drug administration, Clock mutant and Bmal1 knockout mice are hi...

2014
Akiko Hida Shingo Kitamura Yasuko Katayose Mie Kato Hiroko Ono Hiroshi Kadotani Makoto Uchiyama Takashi Ebisawa Yuichi Inoue Yuichi Kamei Masako Okawa Kiyohisa Takahashi Kazuo Mishima

A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced...

2014
Kyoko Oh-oka Hiroshi Kono Kayoko Ishimaru Kunio Miyake Takeo Kubota Hideoki Ogawa Ko Okumura Shigenobu Shibata Atsuhito Nakao

BACKGROUND & AIMS The circadian clock drives daily rhythms in behavior and physiology. A recent study suggests that intestinal permeability is also under control of the circadian clock. However, the precise mechanisms remain largely unknown. Because intestinal permeability depends on tight junction (TJ) that regulates the epithelial paracellular pathway, this study investigated whether the circ...

2013
Natalia Paladino José M Duhart Malena L Mul Fedele Diego A Golombek

UNLABELLED BACKGROUND The relation between circadian dysregulation and cancer incidence and progression has become a topic of major interest over the last decade. Also, circadian timing has gained attention regarding the use of chronopharmacology-based therapeutics. Given its lack of functional T lymphocytes, due to a failure in thymus development, mice carrying the Foxn1(Δ/Δ) mutation (nude...

Journal: :CoMPHI Journal 2022

Globally, it is estimated that around 422 million adults had diabetes in 2014. Diabetics then have a higher risk of developing other diseases, such as: stroke and heart attack. Circadian rhythm disorders as sleep are one the factors causing type 2 mellitus. This study isintended to increase knowledge basis for further research on effect circadian misalignment mellitus determine diabetes. litera...

2010
Leandro P Casiraghi Diego O Croci Francoise Poirier Gabriel A Rabinovich Diego A Golombek

BACKGROUND Recent evidence suggests a two-way interaction between the immune and circadian systems. Circadian control of immune factors, as well as the effect of immunological variables on circadian rhythms, might be key elements in both physiological and pathological responses to the environment. Among these relevant factors, galectin-1 is a member of a family of evolutionarily-conserved glyca...

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