CIC/Capicua is an HMG-box transcription factor that is well conserved during evolution. CIC recognizes the T(G/C)AATG(A/G)A sequence and represses its target genes, such as PEA3 family genes. The receptor tyrosine kinase/RAS/MAPK signals downregulate CIC and relieves CIC's target genes from the transrepressional activity; CIC thus acts as an important downstream molecule of the pathway and as a...

Epithelial renewal in the Drosophila intestine is orchestrated by Intestinal Stem Cells (ISCs). Following damage or stress the intestinal epithelium produces ligands that activate the epidermal growth factor receptor (EGFR) in ISCs. This promotes their growth and division and, thereby, epithelial regeneration. Here we demonstrate that the HMG-box transcriptional repressor, Capicua (Cic), mediat...

Inactivating mutations in the transcriptional repression factor Capicua (CIC) occur in approximately 50% of human oligodendrogliomas, but mechanistic links to pathogenesis are unclear. To address this question, we generated Cic-deficient mice and human oligodendroglioma cell models. Genetic deficiency in mice resulted in a partially penetrant embryonic or perinatal lethal phenotype, with the pr...

BACKGROUND The aim of this study was to investigate the effects of Ramadan fasting on neutrophil's respiratory burst and circulating immune complex (CIC) level. METHODS The effects of Ramadan fasting on neutrophil's respiratory burst and CIC was studied in 21 normal young fasting Muslim individuals using standardized chemiluminescence and poly ethylene glycol methods respectively, the results...

We have previously reported that 14-d chronic intermittent cold (CIC) stress induced a cognitive deficit in reversal learning on the rat attentional set-shifting test. This effect may be related to dysregulation of 5-HT function in orbitofrontal cortex, as a model of cognitive dysfunction in depression. To test the ability of chronic antidepressant drug treatment to reverse the cognitive defici...

A1 5th German Conference on Chemoinformatics: 23. CIC-Workshop. November 8-10, 2009, Goslar, Germany Frank Oellien, Uli Fechner, Thomas Engel GDCh-CIC Division Chair, Intervet Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany; GDCh-CIC division board member, BeilsteinInstitut zur Förderung der Chemischen Wissenschaften, Trakehner Str. 7-9, 60487 Frankfurt, Germany; GDCh-CIC Division Co...

In a group of 46 patients with retinitis pigmentosa (RP) we studied the presence of circulating immune complexes (CIC) and the alterations in the complement system. Our results showed the presence of CIC in 43.5% of the patients studied, reduced levels of the complement components C3 and C4 (p less than 0.001), and of the haemolytic activity CH50 (p less than 0.001) when compared with a control...

R Vaishnavi , V Elamaran Department of Electronics and Communication Engineering School of EEE, SASTRA University Thanjavur, India [email protected] Assistant Professor, Department of Electronics and Communication Engineering School of EEE, SASTRA University Thanjavur, India [email protected] Abstract: In this paper a Cascaded integrated comb (CIC) filter, an optimized class of linea...

This paper is concerned with design of cascading CIC filter and FIR filter to improve the passband droop and stopband attenuation for decimation filter. Decimation filter has wide application in both analog and digital systems for data rate conversion as well as filtering. We have three class of filters FIR, IIR and CIC filters. IIR filters are simpler in structure, but not satisfy linear phase...

Complement receptor one (CR1) is essential for removing circulating immune complexes (CIC), with malaria infection contributing to the formation of large amounts of CIC. We investigated CIC levels in children with malaria, of varying severity and seasonality. Two hundred age and sex-matched severe and mild malaria cases were studied during and after active disease. Pediatric controls had increa...