Normal wound healing is a dynamic and complex process involving coordinated interactions between diverse immunological and biological systems. If a wound does not heal in an orderly and timely sequence, or if the healing process does not result in structural integrity, then the wound is considered chronic. It is easy to define a chronic wound, but finding a solution is a complicated matter. Con...

Oxygen is essential for all stages of wound healing. Previous research has shown topical administration of oxygen to have positive effects on wound healing. In this study, the application of transdermal continuous topical oxygen therapy (TCOT) was evaluated for its effect on chronic wound healing in 9 patients. After 4 weeks of treatment, mean wound surface area and wound infection checklist sc...

Four patients with chronic post-operative wound infections and wound gapping that failed to respond to antibiotics were treated by allogeneic macrophage transfusions. No harmful effects were observed following macrophage transfusion and the chronic infections were eradicated in the treated patients with complete healing of wounds. Haemoglobin and white cell count were increased after cell trans...

For decades tumors have been recognized as "wounds that do not heal." Besides the commonalities that tumors and wounded tissues share, the process of wound healing also portrays similar characteristics with chronic fibrosis. In this review, we suggest a tight interrelationship, which is governed as a concurrence of cellular and microenvironmental reactivity among wound healing, chronic fibrosis...

Chronic Q fever is most commonly associated with culture-negative endocarditis and less frequently with infection of vascular grafts, infection of aneurysms, hepatitis, pulmonary disease, osteomyelitis, and neurological abnormalities. We report a case of chronic sternal wound infection, polyclonal gammopathy, and mixed cryoglobulinemia in which Q fever endocarditis was subsequently diagnosed. P...

PURPOSE To provide an overview of moisture management and its importance in wound care. TARGET AUDIENCE This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES After participating in this educational activity, the participant should be better able to:1. Summarize causes and treatments for moisture balance issues of chronic...

Chronic ulcers are a major problem in health care worldwide [1–5]. Wound care is a much neglected field in Sri Lanka. Care of a wound, and advising and supervising the medical team to carry out the necessary measures in wound care, is a basic duty of a clinician. Wounds are an ideal opportunity to demonstrate the ‘art and science of healing’. Patients with chronic wounds are often shunned by th...

Vrana is a clinical condition which occupies the area of skin and remains till body survives. Dushta having features Durgandha (bad smell), Pooyayukta (pus filled), Utsangi (elevated), Chirakali (chronic), Dooshita (afflicted by Tridosha vitiation), Atigandha Varna Srava (discharge with excessive odour coloured), Vedanayukta (painful) opposite to Shuddha (healing wound). Diabetic foot ulcer glo...

Diabetic foot ulcers lead to substantial morbidity and impair quality of life with high treatment costs enormous economic losses. readily become chronic; all too often these wounds do not heal primarily. Treatment chronic should be essentially directed against the main etiologic factors responsible for wound. There are different approaches wound healing in diabetic ulcers. If is based on pathol...

Hepatocyte growth factor-like protein (HGFl) and its receptor, Recepteur d'Origine Nantais (RON), have been implicated in the development of wound chronicity. HGFl and RON expression was detected in acute wound tissue, chronic wound tissue and in normal skin using quantitative polymerase chain reaction (Q-PCR). HGFl and RON expression was also assessed in chronic healing and chronic non-healing...