The progression of chronic renal failure (CRF) levels.2,6 In the MRFIT study, the risk of developing ESRD increased exponentially with increasing levels remains one of the main challenges in clinical neph-rology. Over the last quarter of a century, animal of blood pressure.4 Patients with underlying chronic renal disease are also at increased risk from hyper-experimentation has identified many ...

background the aim of this survey was to explore the baseline knowledge of the iranian community about chronic kidney disease (ckd) definition and its two main risk factors, i.e. diabetes and hypertension. this study also introduced a model of public education program with the purpose of reducing the incidence of ckd in high-risk groups and thereby decreasing the economic burden of ckd in iran....

conclusions although we found a trend towards decreasing spah and improving 6mwd, no statistically significant shift were detected in our outcomes due to inadequate sample size. patients and methods a registered (irct201108257411n1), triple-blind, randomized controlled trial was performed in rasoule akram hospital, tehran, from 2009 to 2011. forty five patients with secondary pulmonary hyperten...

BACKGROUND CXCR4 is the receptor for chemokine CXCL12 and reportedly plays an important role in systemic vascular repair and remodeling, but the role of CXCR4 in development of pulmonary hypertension and vascular remodeling has not been fully understood. METHODS In this study we investigated the role of CXCR4 in the development of pulmonary hypertension and vascular remodeling by using a CXCR...

I report the case of a woman with systemic lupus erythematosus who had pulmonary hypertension unassociated with chronic interstitial lung disease or pulmonary emboli. She had started taking the contraceptive pill seven months previously.

Chronic two-kidney, one clip (2K1C) renovascular hypertension is characterized by a largely angiotensin-independent elevated blood pressure (BP). We hypothesized that the long-term effect of hypertension would compromise endothelium-derived nitric oxide (NO) and diminish its influence in controlling renal perfusion. We determined the influence of endothelium-derived NO on renal hemodynamics and...

BACKGROUND Pulmonary arterial hypertension with systemic dysfunctions, including metabolic disorders and renal dysfunction, has a poor prognosis. However, it remains to be elucidated whether chronic thromboembolic pulmonary hypertension (CTEPH) is also associated with systemic dysfunctions, and if so, whether balloon pulmonary angioplasty (BPA) improves them. METHODSANDRESULTS Fifty-five cons...

Seven women with primary pulmonary hypertension underwent hemodynamic evaluation, at rest and during exercise, before and after the oral administration of captopril. Dose-response curves were generated for the 25-, 50- and 100-mg doses. Captopril significantly reduced systemic blood pressure and systemic vascular resistance; these effects persisted at submaximal levels of exercise. Captopril di...

Nicotine is absorbed in substantial quantities from smokeless tobacco and could contribute to the adverse consequences of smokeless tobacco use. Chronic systemic exposure to nicotine could contribute to accelerated coronary artery disease, acute cardiac ischemic events, and hypertension. Systemic absorption of sodium and mutagenic chemicals from smokeless tobacco could aggravate hypertension or...