we present a 24-year-old female referred with non-healing wound of a few days duration on anterior aspect of her right foreleg. biopsy of the wound was reported to be pyoderma gangrenosum on pathologic report. further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia. treatment with granulocyte colony-stimulating factor (g-csf) r...

The aim of the study was to determine the effects of wound, patient and treatment attributes on wound healing rate and to propose a system for wound healing rate prediction. Predicting the wound healing rate from initial wound, patient and treatment data collected in our database of 300 chronic wounds was not possible. After considering weekly follow-ups, we determined that the best prognostic ...

Vacuum-assisted wound closure (VAC) is a non-invasive, active, wound management therapy exposing the wound bed to local sub-atmospheric negative pressure through a closed system in order to facilitate wound healing. Initially introduced in human medicine for the treatment of chronic wounds, VAC removes fluid from the extra vascular space, improving circulation and enhancing the proliferation of...

introduction: the effectiveness of low power lasers for incisional wound healing, because of conflicting results of previous research studies, is uncertain. therefore, this study was carried out to evaluate low power laser effects on incisional wound healing. materials and methods: incisional wound was produced on thirty-six mature male guinea pigs under general and local anesthesia. in half of...

A chronic wound is that wound which does not heal in an regular set of stages and in a expected amount of time or wounds that do not heal within three months are often considered chronic. Chronic wounds often remain in the inflammatory stage for long time. and some never heal or may take years together . Chronic wound patients most often report pain as dominant in their lives. It has been obser...

Introduction: Several factors such as diseases, medications and humoral agents can delay or speed up wound healing process. Because of the limited information about the hormonal changes during wound healing, in this study the relationship between serum levels of growth hormone, insulin and cortisol and wound healing in normal and diabetic rats was evaluated. Methods: Male Wistar rats )weigh...

Chronic non healing wounds have an elevated alkaline environment. The acidic pH of Manuka honey makes it a potential treatment for lowering wound pH, but the duration of effect is unknown. Lowering wound pH can potentially reduce protease activity, increase fibroblast activity and increase oxygen release consequently aiding wound healing. The aim of this study was to analyse the changes in surf...

In more than a decade of clinical use of electrical stimulation to accelerate the chronic wound healing each patient and wound were registered and a wound healing process was weekly followed. The controlled study involved a conventional conservative treatment, sham treatment, biphasic pulsed current, and direct current electrical stimulation. A quantity of available data suffices for an analysi...

AIM To estimate the cost-effectiveness of silver dressings using a health economic model based on time-to-wound-healing in hard-to-heal chronic venous leg ulcers (VLUs). BACKGROUND Chronic venous ulceration affects 1-3% of the adult population and typically has a protracted course of healing, resulting in considerable costs to the healthcare system. The pathogenesis of VLUs includes excessive...

Oxygen is essential for all stages of wound healing. Previous research has shown topical administration of oxygen to have positive effects on wound healing. In this study, the application of transdermal continuous topical oxygen therapy (TCOT) was evaluated for its effect on chronic wound healing in 9 patients. After 4 weeks of treatment, mean wound surface area and wound infection checklist sc...