To clarify the health risks related to silver nanoparticles (Ag-NPs), we evaluated the genotoxicity, acute oral and dermal toxicity, eye irritation, dermal irritation and corrosion and skin sensitisation of commercially manufactured Ag-NPs according to the OECD test guidelines and GLP. The Ag-NPs were not found to induce genotoxicity in a bacterial reverse mutation test and chromosomal aberrati...

In recent years, it has become evident that it is necessary to systematically and accurately define particle characteristics in order to understand the potential toxicity of nanoparticles to biological systems. The properties that need to be emphasized are size, shape, dispersion, doping, aggregation, functionalization, physical and chemical properties, surface area, and surface chemistry. Rout...

background: there is unprecedented increase in the processing and packaging of many plant materials into food supplements, herbal medicine, skincare and cosmetic products for human needs. baphia nitida is used for topical skincare products. toluene, a toxic aromatic solvent, is increasingly being used in the production of these skincare and cosmetic products in many industries. this study asses...

Lubricating oil base stocks (LOBs) are substances used in the manufacture of finished lubricants and greases. They are produced from residue remaining after atmospheric distillation of crude oil that is subsequently fractionated by vacuum distillation and additional refining steps. Initial LOB streams that have been produced by vacuum distillation but not further refined may contain polycyclic ...

Explanation.................................................................................................. 256 Evaluation for acceptable daily intake......................................................... 256 Biochemical aspects............................................................................... 256 Absorption, distribution, and excretion ...........................................

As a result of growing applications of manufactured nanoparticles, there is an increasing concern aboutpossible side effects of exposure to these materials on human and environment. Nanosilver (n-Ag) has foundwide use in medical applications including development of silver-based dressings and silver-coated medicaldevices. However, toxicity of these particles clue to their dermal use has not bee...

In this study, 602 samples were tested by the following assays performed at the animal facilities (Cedeme) of the Federal University of São Paulo (UNIFESP): 385 for dermal irritability, 90 for ocular irritability (discontinued in 1995), 31 for systemic toxicity by injection, 26 for oral acute toxicity, 15 for toxicity by intracutaneous injection, 15 for skin sensitization, 15 for toxicity of se...

Silver nanoparticles (Ag NPs) have been widely used as new potent antimicrobial agents in cosmetic and hygienic products. Present study compares the tissue levels of Ag NPs in different organs of Guiana Pigs quantitatively after dermal application and analysis the morphological changes and pathological abnormalities on the basis of the Ag NPs tissue levels. Before toxicological assessments,the...