AIM AND BACKGROUND Three simple, accurate and sensitive spectrophotometric methods for the determination of finasteride in pure, dosage and biological forms, and in the presence of its oxidative degradates were developed. MATERIALS AND METHODS These methods are indirect, involve the addition of excess oxidant potassium permanganate for method A; cerric sulfate [Ce(SO4)2] for methods B; and N-...

IPublished methods for the determination of plasma triglycerides are of two kinds, enzymatic (1-3) and colorimetric (4-7). Both require preliminary removal of phospholipids and saponification of triglycerides. With the enzymatic method, glycerin released is quantitatively determined with the specific enzyme GPDH’ and NAD. In the colorimetric methods, glycerin is oxidized to formaldehyde with pe...

A rapid, selective and sensitive method for the preconcentration and determination of uranium (VI) by cloud point extraction (CPE) was developed. The method was based on the color reaction of 5.00 ng mL uranium (VI) with 1.5×10 mol L of chromotrope 2R in the presence of 0.015 mol L potassium iodide at pH 8 in HEPES buffer and mixed micelle-mediated extraction of complex. The mixture of a nonion...

Some years ago an experiment was briefly reported (25) in which it was found that a single subcutaneous injection of 0.1 cc. of heparin (Vitrum, Stockholm) into mice at the expected time of emergence of 1, 2, 5, 6dibenzanthracene-induced papillomas not infrequently led to the localization of a tumor in a small elliptical wound placed over the wheal raised by the injection in the painted area. O...

Some years ago an experiment was briefly reported (25) in which it was found that a single subcutaneous injection of 0.1 cc. of heparin (Vitrum, Stockholm) into mice at the expected time of emergence of 1, 2, 5, 6dibenzanthracene-induced papillomas not infrequently led to the localization of a tumor in a small elliptical wound placed over the wheal raised by the injection in the painted area. O...

OBJECTIVES Trichostatin A (TSA), an inhibitor of histone deacetylase, has been shown to play an important role in attenuating asthmatic inflammation. However, the effect of TSA in allergic rhinitis is not known. The aims of this study were to investigate the effect of TSA on allergic nasal inflammation and on the induction of regulatory T cells in a murine model of allergic rhinitis. METHODS ...

BACKGROUND Microsporidiasis, which is of great concern for immunocompromised patients, is poorly studied in developing countries. OBJECTIVES A study was carried out amongst HIV-positive hospital patients and HIV-negative hospital controls in Ilorin, Nigeria, between January 2009 and July 2010 to determine the prevalence and intensity of Microsporidium spores and the complications associated w...