chromosomal defects are relatively frequent in infertile men however, translocations between the y chromosome and autosomes are rare and less than 40 cases of y-autosome translocation have been reported. in particular, only three individuals has been described with a y;21 translocation, up to now. we report on an additional case of an infertile man in whom a y;21 translocation was associated wi...

Background and Aims: Azoospermia factor (AZF) region of the Y-chromosome has several genes which are responsible for normal spermatogenesis. Microdeletions of these genes are associated with azoospermia and oligospermia. These microdeletions are too small to be detected by karyotyping. They can be easily identified using polymerase chain reaction. The aim of this study is to determine the frequ...

HE advantages of using Arabidopsis, a small crucifer, for studies of mutation Tand other genetic problems were pointed out by G. P. R ~ D E I (1962). His establishment of five linkage groups ( R~~DEI , private communication) and the occurrence of certain aberrant mutants made a study of Arabidopsis chromosomes desirable. The following is a report on the cytology of normal Arabidopsis thaliana (...

The finding of an inherited chromosome abnormality (Chl) in several members of a family, including two who had developed chronic lymphocytic leukaemia (Gunz, Fitzgerald, and Adams, i962), led to the suggestion that this abnormality predisposed its carriers to the development of the disease, and that inherited cytogenetic abnormalities of this type might determine some instances of familial leuk...

background: cytogenetic analysis, y-chromosome microdeletion screening, fish techniques and other genetic methods have helped in finding the causes of infertility in azoospermic or severe oligoazoospermic cases in the last decade. objective: in the present study, we characterized an abnormal y-chromosome, detected as a mosaic in an azoospermic male ascertained for infertility. materials and met...

Introduction Cytogenetic analysis of malignant cells very often indicates acquired chromosome changes-that is, deviations from the normal constitutional 46,XX or 46,XY karyotype. Much of what we know about these changes is derived from studying leukaemias and lymphomas. Many of these abnormalities are nonrandom, and particular chromosome changes are consistently found in particular disease type...

We have used micromanipulation to study the attachment of chromosomes to the spindle and the mechanical properties of the chromosomal spindle fibers . Individual chromosomes can be displaced about the periphery of the spindle, in the plane of the metaphase plate, without altering the structure ofthe spindle or the positions of the nonmanipulated chromosomes . From mid-prometaphase through the o...

The Human Genome Project has generated a blueprint for the approximately 20,300 gene-encoded proteins potentially active in any of 230 cell types that make up the human body (human proteome). However, based on the UniProtKB/Swiss-Prot database content, about 6000 of at the protein level; for many others, there is very little information related to protein function, abundance, subcellular locali...