The blue butterfly species Polyommatus (Plebicula) atlanticus (Elwes, 1906) (Lepidoptera, Lycaenidae) is known to have a very high haploid number of chromosomes (n= circa 223). However, this approximate count made by Hugo de Lesse 45 years ago was based on analysis of a single meiotic I metaphase plate, not confirmed by study of diploid chromosome set and not documented by microphotographs. Her...

INTRODUCTION To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) in detecting MET and IGF1R alterations and to investigate their prevalence and prognostic significance. A possible correlation between MET receptor expression, MET gene alterations and the two most frequent occurring EGFR gene mutations was also investigated. MATERIALS AND METHODS Stage ...

BACKGROUND Eosinophils are granulocytic white blood cells implicated in asthma and atopic disease. The degree of eosinophilia in the blood of patients with asthma correlates with the severity of asthmatic symptoms. Quantitative trait loci (QTL) linkage analysis of eosinophil count may be a more powerful strategy of mapping genes involved in asthma than linkage analysis using affected relative p...

We present a formal account of a genetic mechanism for Environmental Sex Determination (ESD) using a probabilistic process algebra (WSCCS). We exploit the process algebra to demonstrate that a single chromosome pair based polyfactorial system is intrinsically unstable. The system evolves, with a deterministic relationship between an animal's sex and its polyfactor count, to three possible forms...

Among 3,638 children with acute lymphoblastic leukemia (ALL) entered on Pediatric Oncology Group (POG) protocols between June 1981 and April 1989, successful cytogenetic studies were available for 2,519, 58 (2.3%) of which had the Philadelphia (Ph) chromosome detected. Features associated with the presence of the Ph chromosome were high leukocyte count (median, 33 x 10(9)/L), older age median, ...

Background: The Y chromosome microdeletion is one of the best-documented causes of male infertility but the factors responsible for Y chromosome microdeletions in spermatozoa remain unresolved. However, the environmental pollutants are known to damage DNA in differentiating and maturing germ cells in the male reproductive tract. In view of this, the objective of the present study was to explore...

To understand plant evolution and diversification, information regarding chromosome number meiotic behavior is imperative. The present study was carried out to determine the count, behavior, pollen fertility, seed set of a medicinally important Peganum harmala. Two cytotypes, diploid tetraploid are growing in western Himalaya; cytotype (2n=2x=24) Kashmir Himalaya, (2n=4x=48) Trans Ladakh. Chrom...

AIM To analyze the clinical characteristics of patients with chronic phase CML and evaluate complete hematologic responses (CHR) and overall survival (OS) after treatment with Imatinib. METHODS This is a cross sectional study using retrospective medical record of patients with chromosome Philadelphia positive and/or BCR-ABL positive chronic phase CML at the polyclinic of Teratai Department of...