نتایج جستجو برای: chromosome 10q
تعداد نتایج: 119424 فیلتر نتایج به سال:
Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants within TCF7L2 on chromosome 10q were recently reported to be associated with type 2 diabetes in Icelandic, Danish, and American (U.S.) samples. We previously observed a modest logarithm of odds score of 0.61 on chromosome 10q, approximately 1 Mb from TCF7L2, in the Finland-United States Investigation o...
We describe an 18 year old male with an interstitial development. This was characterized by dysplasia of the genital organs, absence of axillary hair and sparse pubic hair and a female like physique with bilateral gynaecomastia. Other clinical findings included severe mental retardation and minor anomalies , both of which were consistent with other reports. A review of the literature revealed 1...
A severely mentally subnormal child with many physical stigmata was shown to have the karyotype 46,XY,-2,+der(2),t(2;10)(q31;q24)pat. Full evaluation of this patient's karyotype depended on the family studies. It was shown that a balanced translocation t(2,10) was present in 4 normal males in 3 generations.
Numerous studies have detected frequent losses of heterozygosity at polymorphic loci on chromosomal arms 10p and 10q in human prostate cancers. To confirm the presence of tumor suppressor genes in these chromosomal regions, fragments of normal human chromosome 10 tagged with a neomycin resistance gene were transferred into cells from a human prostate cancer cell line. PPC-1, by microcell-mediat...
Recent studies have shown that the clinical outcome of anaplastic oligodendroglial tumors is variable, but also that the histological diagnosis is subject to interobserver variation. We investigated whether the assessment of 1p/19q codeletion, polysomy of chromosome 7, epidermal growth factor receptor (EGFR) gene amplification (EGFR(amp)), and loss of chromosome 10 or 10q offers additional prog...
esults: Significant linkage for P3 amplitude was observed on chromosome 7q for the central recording site (logarithm-of-odds [LOD] .88, p .00002) and in the same region for both frontal (LOD 2.19, p .0015) and parietal (LOD 1.67, p .0053) sites, with multivariate nalysis also identifying linkage in this region (LOD 2.14, p .0017). Suggestive linkage was also identified on 6p (LODmax 2.49) and 1...
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