The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

DNA is organized into chromatin, a complex polymeric material that stores information and controls gene expression. An emerging mechanism for biological organization, particularly within the crowded nucleus, biomolecular phase separation condensed droplets of protein nucleic acids. However, way in which chromatin impacts dynamics condensate formation poorly understood. Here we utilize powerful ...

background: exposures to lead above the threshold value of 50–60 μg/dl have been linked to diminished semen quality parameters. worldwide, the lead exposure has been diminished during the last years. therefore, it has become of a great concern to examine the effects of lead exposures on semen quality at low levels of exposure. objective: to evaluate the effect of low level (<20 μg/dl) blood lea...

• We propose 7 ways for nucleosome binding proteins to affect higher order structure. Choices on nucleosomal array conditions impact protein and overall Chromatin phase separation is driven by a range of interactions the nucleosome. The regulation chromatin biology ultimately depends manipulation its smallest subunit, that bind operate do so, while their substrate part polymer embedded in dense...

Abstract Evolutionarily young genes are usually preferentially expressed in the testis across species. Although it is known that older generally more broadly than younger genes, properties shaped this pattern unknown. Older may gain expression other tissues uniformly, or faster certain others. Using Drosophila gene data, we confirmed previous findings disproportionately biased and ovary biased....

Central dogma is the most fundamental hypothesis in field of molecular biology and explains genetic information flow from DNA to protein. Beyond residue-by-residue transmission sequential information, chemical modifications DNA, RNA, protein are also relayed course gene expression. Here, this work presents recent evidence supporting bidirectional interplay between chromatin RNA modifications. F...

facioscapulohumeral muscular dystrophy (fshd)is characterized by weakness of the facial, scapular muscles  and the dorsiflexors of the foot. severity in this disorder is highly variable. approximately 95% of individuals with fshd phenotype have type 1 fshd, with d4z4 allele of between one and ten repeat units and about 5% have type 2 fshd with mutations in the chromatin modifier smchd1gene whic...