Intracerebral hemorrhage as initial presentation of nongestational choriocarcinoma is extremely rare. The therapy includes surgery, chemotherapy and radiotherapy. Nongestational metastatic choriocarcinoma has a poor treatment effect and a dismal prognosis. This study is to report a rare case of intracerebral hemorrhage as initial presentation of unknown primary of nongestational choriocarcinoma...

Gestational choriocarcinoma is a rare and aggressive type of gestational trophoblastic neoplasia, which is characterized by early vascular invasion and widespread metastases. Choriocarcinoma metastasizes hematogenously, and bleeding from metastases is common. Splenic rupture from a metastatic tumour is exceedingly rare, with only a few reports. We report a case of a 41-year-old female presentin...

BACKGROUND Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hypermethylation and loss of the tumor suppressor Retinoic acid receptor respon...

Placental choriocarcinoma is a highly malignant tumor of the female reproductive organs. Even with chemotherapy, placental choriocarcinoma has a 20% mortality rate due to its indistinct pathogenesis and the absence of efficient therapeutic methods for this cancer. Wnt proteins and Wnt signaling are involved in a variety of developmental and cellular processes, and aberrant activation of Wnt sig...

Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and less frequently, the brain. Metastases to the kidney are rare in the literature, and bilateral involvement is even more scarce. Renal involvement of choriocarcinoma is highly exceptional and may mimic renal cell carcinoma. Here we report a case of bilater...

BACKGROUND Chemotherapy is typically used to treat choriocarcinoma, but a small proportion of tumors develop resistance to chemotherapy. Similarly, methotrexate (MTX) is a first-line chemotherapy used to treat choriocarcinoma; although ~30% of patients are drug-resistant for MTX mono-therapy. Thus, we sought to elucidate the mechanism of chemotherapeutic-resistance of MTX. METHODS RNA interfe...

Abstract Gestational trophoblastic tumors seriously endanger child productive needs and the health of women in childbearing age. Nanodrug-based therapy mediated by transporters provides a novel strategy for treatment tumors. Focusing on overexpression human equilibrative nucleoside transporter 1 (ENT1) membrane choriocarcinoma cells (JEG-3), cytarabine (Cy, substrate ENT1)-grafted liposomes (Cy...

gestational choriocarcinoma usually occurs following an intrauterine pregnancy. we report a case of metastatic choriocarcinoma to the left kidney and lungs with long term intermittent amenorrhea and vaginal bleeding after a normal vaginal delivery. a 43 year old rural woman presented with three years intermittent amenorrhea and vaginal bleeding following normal vaginal delivery. she also compla...

The clinical presentations of gestational choriocarcinoma vary markedly, and a misdiagnosis could be made in atypical patients if simply relying on clinical features. Laparoscopic resection of uterine mass lesion is rarely used in gestational choriocarcinoma diagnosis because of the fear of heavy blood loss and distant metastasis. Five patients who were preoperatively diagnosed as having cornua...