نتایج جستجو برای: chloroquine diphosphate
تعداد نتایج: 39447 فیلتر نتایج به سال:
One of the most important drug which use in malaria treatment is chloroguine, this drug has schizontocidal effect (except in the cases of plasmodium falciparum resistance to chloroquine). Primaquine had effect on exoerythrocytic stage of malaria parasite and use for radical cure of malaria. Quinine is a useful drug especially in cerebral malaria treatment. Today antibiotic. Mefloquine , su...
ABSTRACT In this research effect of chloroquine on oestrus cycle,(Follicle Stimuloting Hormone)FSH and (Luteinizing Hormone) LH has been evaluated. There were three groups. Group I (control rats) received an equal volume of physiological salin. Group II animals had chloroquine (25 mg/kg) administered intraperitoneally (I.P) for 3 days and group III animals received chloroquine 30 mgkg for ten d...
In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria. To determine whether withdrawal of chloroquine can lead to the reemergence of chloroquine sensitivity, the prevalence of the pfcrt 76T molecular marker for chloroquine-resistant Plasmodium falciparum malaria was ...
Chloroquine-(14)C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei. The initial rates of uptake and exchange of chloroquine-(14)C were both too fast to measure, yet large concentration gradients were maintained by the cells. When red blood cells were exposed to 10(-8)M chlo...
Background and Objective: Resistance to chloroquine (CQ) in Plasmodium falciparum malaria has become a major health concern in the developing countries. This problem has prompted investigators for finding alternative antimalarials that may be effective against resistant strains. Amodiaquine (AQ) is an antimalarial which is effective against many chloroquine-resistant strains of P. falciparum. H...
Glucose stimulates the high-affinity processes of chloroquine and amodiaquin accumulation in owl monkey erythrocytes infected with a chloroquine-susceptible strain of Plasmodium falciparum. Although these erythrocytes have greater ability to accumulate amodiaquin than chloroquine, glucose has relatively less effect on amodiaquin accumulation than on chloroquine accumulation. In contrast to thes...
The advent of chloroquine promising activity against the COVID-19 is novel and as such, it is imperative to thoroughly understand and determine the rate at which individual body systems handle the drug. Chloroquine a known antimalarial drug belongs to the chemical class of 4-aminoquinolines. The aim of the study was to analyze Chloroquine and its metabolite in biological fluids of healthy subje...
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