N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) are antimicrotubule agents interacting covalently with β-tubulin near the colchicine-binding site (C-BS). Glutamyl 198 residue in β-tubulin (Glu198), which is adjacent to the C-BS behind the two potent nucleophilic residues, Cys239 and Cys354, has been shown to covalently react with 1-(2-chloroethyl)-3-(4-iodophenyl)urea (ICEU). By use of mass spectrometr...

N-Phenyl-N -(2-chloroethyl)ureas (CEUs) are antimicrotubule agents interacting covalently with -tubulin near the colchicine-binding site (C-BS). Glutamyl 198 residue in -tubulin (Glu198), which is adjacent to the C-BS behind the two potent nucleophilic residues, Cys239 and Cys354, has been shown to covalently react with 1-(2-chloroethyl)-3-(4iodophenyl)urea (ICEU). By use of mass spectrometry, ...

inclusion 643 articles Full text inclusion 143 articles Foreign language articles: Norwegian: 22 Swedish: 9 Finnish:1 Russian: 2 German: 1 Japanese: 1 6 articles added from bibliographies Fish: 50 articles articles not relevant to the 866 question 2742 articles not relevant 464 articles not included, Including 43 articles that may contain relevant information but can not be obtained Phytoplankt...

OBJECTIVE Sulfur mustard is a well-known blistering chemical warfare agent that has been investigated for its toxicological mechanisms and an efficacious antidote. Since sulfur mustard injury involves dermal:epidermal separation, proteolytic enzymes were suspected to be involved for this separation and eventual blister development. Therefore, protease inhibitors could be of therapeutic utility ...

As the new Editor in Chief, I will use this editorial to give a brief outline of my vision for the future of the journal. As the english-language successor to the dutch-language journal of the Dutch Association for Medical Education (NVMO), ‘Perspectives on Medical Education’ has become a fully-fledged international scientific journal. I commend the editorial board on this achievement. It provi...

By MARC SCHUT†‡§, LAURENS KLERKX‡, MURAT SARTAS†‡¶, DIEUWKE LAMERS†, MARIETTE MC CAMPBELL††, IFEYINWA OGBONNA††, PAWANDEEP KAUSHIK††, KWESI ATTA-KRAH‡‡ and CEES LEEUWIS‡ †International Institute of Tropical Agriculture (IITA), Quartier Kabondo, Rohero 1, Avenue 18 Septembre 10, Bujumbura, Burundi, ‡Knowledge, Technology and Innovation Group, Wageningen University, P.O. Box 8130, 6700 EW, Wageni...

This paper discusses the role of donor organizations during the transition process of CEE countries. Previous research pointed to them as the ones to blame for the failure of many assistance projects. This paper investigates what those donor organizations have to say themselves. It departs form the theory of social exchange which focuses on situations of imbalance of costs and rewards which is ...

Since late 1980s four systems of stages of higher education and qualifications have been in force in Estonia. The higher education system has been changed or reorganized through three phases of reforms, important periods were in 1989-1991, 1995-1996 and 20012002. The latter phase of reforms was clearly facilitated and conducted by the progressive Bologna process. Similarly to other CEE countrie...

In this paper we discuss the new demands put on university faculty for involvement in delivery of Continuing Engineering Education. CEE programmes are often composed in the same way as on-campus programmes – which means straight forward for teachers to conduct. However, the needs for new knowledge and new competencies in small and medium sized enterprises and for teams in larger enterprises are...

We have previously shown that vanadium bromoperoxidase from Ascophyllum nodosum mediates production of the (R)-enantiomer of methyl phenyl sulfoxide with 91% enantiomeric excess. Investigation of the intrinsic selectivity of vanadium bromoperoxidase reveals that the enzyme catalyzes the sulfoxidation of methyl phenyl sulfide in a purely enantioselective manner. The K(m) of the enzyme for methyl...