Infection with the bacterium, Chlamydia trachomatis (often termed "chlamydia") is the most frequently reported sexually transmitted infection in the United States. The urethra is the most common site of infection in males, and the urethra and cervix are most commonly infected in females. Ascending infection in females can cause pelvic inflammatory disease, which can lead to infertility and ecto...

BACKGROUND The majority of Chlamydia trachomatis infections in women are asymptomatic, but may give rise to pelvic inflammatory disease (PID) and tubal infertility. Screening programmes aim at reducing morbidity in individuals by early detection and treatment, and at decreasing the overall prevalence of infection in the population. A number of modelling studies have tried to calculate the thres...

Infection of epithelial cells by the intracellular pathogen, Chlamydia trachomatis, leads to activation of NF-kappaB and secretion of pro-inflammatory cytokines. We find that overexpression of a dominant-negative Nod1 or depletion of Nod1 by RNA interference inhibits partially the activation of NF-kappaB during chlamydial infection in vitro, suggesting that Nod1 can detect the presence of Chlam...

Chlamydia species infect epithelial cells at mucosal surfaces, and are major causes of sexually transmitted diseases. Infection is characterized by inflammation which is exacerbated upon reinfection, ultimately leading to tissue damage and scarring. Although central for the development of disease manifestations, little is known about the mechanisms that initiate and sustain the inflammatory res...

CONTEXT Black women are disproportionately infected with gonorrhea and chlamydia. Because of the potential impact of these infections on women's reproductive health, it is important to determine whether different factors are predictive of infection in women of different races. METHODS Data from 31,762 women aged 15-24 who were tested for gonorrhea and chlamydia at Missouri family planning cli...

OBJECTIVE To describe the epidemiology of prevalent and incident chlamydia infection in order to assess the appropriate interval for chlamydia screening; and to identify risk factors predictive of infection and repeat infections. DESIGN Prospective longitudinal study of a consecutive sample of 3860 sexually active females aged 12-60 years tested for C. trachomatis by polymerase chain reaction...

Abstract C. trachomatis infections in women may cause pelvic inflammatory disease, chronic pain, and infertility. In the mouse model, genital Chlamydia disseminates systemically to infect spleen. Removal of spleen (splenectomy) abrogates hydrosalpinx pathology female reproductive tract (FRT), although it does not affect FRT clearance. Ascension upper (uteri, ovaries, oviducts) is critical for d...

chlamydia trachomatis infections are the most prevalent bacterial sexually transmitted infections (sti) recognized throughout the world. the aim of this study was to determine the prevalence of chlamydia trachomatis among a randomized statistical group of women suffering from cervicitis in tehran- iran. during a 12- month- period, jan 2003 to jan 2004, 142 endocervical samples were taken from w...

Chlamydia trachomatis is one of the most common and spoiling sexually transmitted diseases in different countries. It plays an important role in disease such as salpingitis and arthritis, crevicitis, premature rupture of membrane, neonatal infection while passing through the vaginal, infertility and ectopic pregnancy. This study was designed to investigate the prevalence of Chlamydia infection ...

The prevalence of cervical Chlamydia trachomatis infection in general practice populations ranges between 2% and 12%. Untreated infection can cause pelvic inflammatory disease, tubal infertility and ectopic pregnancy. These risks are increased by cervical invasive procedures, especially termination of pregnancy. However, most women with chlamydia infection have no symptoms. General practitioner...