Capsaicin has known health beneficial and therapeutic properties. It is also able to enhance the permeability of drugs across epithelial tissues. Unfortunately, due to its pungency the oral administration of capsaicin is limited. To this end, we assessed the effect of nanoencapsulation of capsaicin, under the hypothesis that this would reduce its pungency. Core-shell nanocapsules with an oily c...

Antitumor activities have been described in selol, a hydrophobic mixture of molecules containing selenium in their structure, and also in maghemite magnetic nanoparticles (MNPs). Both selol and MNPs were co-encapsulated within poly(lactic-co-glycolic acid) (PLGA) nanocapsules for therapeutic purposes. The PLGA-nanocapsules loaded with MNPs and selol were labeled MSE-NC and characterized by tran...

We determined the anticancer efficacy and internalization mechanism of our polymeric-ceramic nanoparticle system (calcium phosphate nanocores, enclosed in biodegradable polymers chitosan and alginate nanocapsules/nanocarriers [ACSC NCs]) loaded with iron-saturated bovine lactoferrin (Fe-bLf) in a breast cancer xenograft model. ACSC-Fe-bLf NCs with an overall size of 322±27.2 nm were synthesized...

The objectives of the present investigation were to prepare the 5-Fluorouracil (5-FU) loaded chitosan microspheres for colon targeting and its in vitro cytotoxicity analysis on HT-29 human colon cancer cell lines. Chitosan microspheres prepared by the emulsion polymerization method were analyzed for morphology, mean particle size, drug polymer interaction, entrapment efficiency, in vitro drug r...

Purpose: To develop chitosan/alginate microparticles for the mucosal delivery of allergen from dust mite (Dermatophagoides pteronyssinus). Methods: Chitosan/alginate microparticles were prepared by ionotropic gelation. The effects of polymer content, crosslinking agent, and preparation method on the physicochemical characteristics of the microparticles as well as their in vitro cytotoxicity wer...

Recent advancements in the synthesis, properties, and applications of chitosan as second after cellulose available biopolymer nature were discussed this review. A general overview processing production procedures from to Z was highlighted. Chitosan exists three polymorphic forms which differ degree crystallinity (?, ?, ?). Thus, deacetylation, crystallinity, surface area, molecular mass signifi...

cell-based biosensors have become a research hotspot in biosensors and bioelectronics fields. the main feature of cell-based biosensors is the immobilization of living cell on the surface of transducers. different types of polymers which are used as scaffolds for cell growth should be biocompatible and have reactive functional groups for further attachment of biomolecules. in this work, the cel...

in this study, fe 3 o 4 superparamagnetic nanoparticles were synthesized and stabilized by chitosan. then the nanoparticles were characterized by fourier transform infrared spectroscopy and transmission electron microscopy (tem). particle size distribution and zeta potential of the particles also was assessed using malvern zetasizer. the paramagnetic behaviors of the uncoated and chitosan coate...

Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thromb...