5-ASA is widely used for its local effects in the treatment of inflammatory bowel diseases (Loftus, 2004). Because of the 4-aminophenol structure and antioxidative properties it is considered as a light, temperature and oxygen sensitive drug and its major degradation products are well established (Jensen, 1992). As a zwitter ion, dominantly anionic, 5-ASA has low aqueous solubility and it is po...

The aim of the present study was to develop novel Mycobacterium bovis bacille Calmette-Guérin (BCG)-loaded polymeric microparticles with optimized particle surface characteristics and biocompatibility, so that whole live attenuated bacteria could be further used for pre-exposure vaccination against Mycobacterium tuberculosis by the intranasal route. BCG was encapsulated in chitosan and alginate...

The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle size, drug loading, encapsulation efficiency and swelling ratio, in vitro drug...

Polyelectrolyte-coated nanoparticles or microparticles interact with bioactive molecules (peptides, proteins or nucleic acids) and have been proposed as delivery systems for these molecules. However, the mechanism of adsorption of polyelectrolyte onto particles remains unsolved. In this study, cationic poly(lactide-co-glycolide) (PLGA) nanoparticles were fabricated by adsorption of various conc...

Background: Biological molecules such as therapeutic proteins and peptides have provided ample opportunities for further improvements in health wellbeing. However, biomacromolecules face stability challenges regarding premature processing digestion, whenever any enteric delivery route is considered. Hence, oral guar films entrapping peptide-containing chitosan microparticles been developed a ne...

In this paper, different formulation types of microparticulate systems such as beads, microbeads, microspheres and microsponges using to special attention chitosan, alginate and eudragit RS 100 are reviewed. Chitosan and alginates are natural, anionic or cationic, biocompatible, biodegredable and non-toxic polymers. They have excellent potential for pharmaceutical and biopharmaceutical applicat...

Novel microparticles based on chitosan and sodium alginate were prepared using emulsification and cross-linking technologies. The spherical microparticles had a porous surface and a diameter of 2 ~ 40 μm. In simulated body fluid, these microparticles quickly swelled but gradually degraded. The results of the MTT assay revealed that a slight inhibition of cell proliferation was observed on day 2...

A polyelectrolyte complex system of chitosan-pectin nano- and microparticles was developed to encapsulate the hormone insulin. The aim of this work was to obtain small particles for oral insulin delivery without chemical crosslinkers based on natural and biodegradable polysaccharides. The nano- and microparticles were developed using chitosans (with different degrees of acetylation: 15.0% and 2...

The aim of the present work was to test the ability of two non-diabetogenic carbohydrates to intranasally deliver the insulinotropic drug repaglinide (REP) for controlling blood glucose level. REP was loaded onto chitosan/alginate nanocomplexes (NCs) suitable for mucosal delivery and uptake. Improved stability and delivery characteristics were obtained by spray drying the selected NCs, yielding...

The incorporation of miconazole nitrate (MCN) in mucoadhesive microparticles made of a water-soluble chitosan salt, chitosan glutamate (CHG) was studied. These solid systems may be proposed for buccal or vaginal applications against mycotic infections, taking advantage of the muco-adhesive and permeation enhancing properties of this polymer. Two series of solid dispersions were obtained by eith...