نتایج جستجو برای: chir pine
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Chicken IgY, the ancestral form of mammalian IgE and IgG, is recognized by the high-affinity FcY receptor CHIR-AB1, a member of the leukocyte receptor family. In this study, we have characterized the receptor ligand interaction site by consecutive truncations of the Fcv IgY domains and mutational analyses of selected residues. Using several fusion proteins that linked the human Cgamma2 and Cgam...
Activin A maintains the pluripotency of human induced pluripotent stem (hiPS) cells. A combination of activin A and CHIR99021 (CHIR), a specific inhibitor of glycogen synthase‑3β, is suitable for feeder‑free culture of hiPS cells. In the present study, the specific role of the Wnt signaling pathway in cells cultured under different conditions was investigated. Following transfection with the re...
This paper is a report of Chinese Text Retrieval (CHTR) tasks in NTCIR Workshop 2. CHTR tasks fall into two categories: Chinese-Chinese IR (CHIR) and English-Chinese IR (ECIR). The definitions, schedules, test collection (CIRB010), search results, evaluation, and initial analyses of search results of CHIR and ECIR are discussed in this paper.
Idem., St. Bart's Hosp. med. Rep., 1912, 43, 73. Idem., Brit. med. J., 1912, ii, 1367. Idem., Brit. J. Surg., 1914, 2, 17. Idem., The Robert Jones Birthday Volume, Oxford University Press, 1928, p. 127. Idem., J. Bone Jt Surg., 1931, 13, 423. ELMSLE, R. C., FRASER, F. R., DUNHLL, T. P., VICK, R. M., HARRIS, C. F., and DAUPHINEE, J. A., Brit. J. Surg., 1933, 20, 479. ELMsLE, R. C., Lpool med.-ch...
PURPOSE Fms-like tyrosine kinase 3 (FLT3) encodes a receptor tyrosine kinase (RTK) for which activating mutations have been identified in a proportion of acute myelogenous leukemia (AML) patients and associated with poor clinical prognosis. Given the relevance of FLT3 mutations in AML, we investigated the activity of CHIR-258, an orally active, multitargeted small molecule, with potent activity...
PURPOSE The ectopically expressed and deregulated fibroblast growth factor receptor 3 (FGFR3) results from a t(4;14) chromosomal translocation that occurs in approximately 15% of multiple myeloma (MM) patients and confers a particularly poor prognosis. This study assesses the antimyeloma activity of CHIR-258, a small-molecule inhibitor of multiple receptor tyrosine kinases that is currently in ...
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