Barrier algorithms are central to the performance of numerous algorithms on scalable, high-performance architectures. Numerous barrier algorithms have been suggested and studied for Non-Uniform Memory Access (NUMA) architectures, but less work has been done for Cache Only Memory Access (COMA) or attraction memory 2] architectures such as the KSR-1. In this paper, we present two new barrier algo...

Prostate cancer is the most frequently diagnosed cancer in men in industrialized countries. Despite the substantial clinical importance of the disease, the mechanisms underlying the development and progression of prostate cancer are poorly understood. In the present study, fragment analysis of chromosome arm 16q was carried out with the aim of searching for sites of consistent chromosomal delet...

Pharmaceutical research often entails making small modifications to candidate drug molecules—modifications that might be deemed “obvious to try”—and then studying the largely unpredictable, yet critical, resulting biological effects. Recognizing this characteristic unpredictability, the U.S. Court of Appeals for the Federal Circuit has traditionally upheld the patentability of obvious-to-try ph...

Barrier algorithms are central to the performance of numerous algorithms on scalable, high-performance architectures. Numerous barrier algorithms have been suggested and studied for Non-Uniform Memory Access (NUMA) architectures, but less work has been done for Cache Only Memory Access (COMA) or attraction memory 2] architectures such as the KSR-1. In this paper, we present two new barrier algo...

One of the most important and delicate judicial tasks in patent law is to keep the obviousness doctrine in reasonable working order. There are several reasons why the obviousness doctrine has been the subject of frequent judicial tinkering. First, patentability doctrines interact with each other, so doctrinal alterations that seem to be entirely external to the obviousness doctrine frequently h...

Vulval differentiation in Caenorhabditis elegans is controlled by a conserved signal transduction pathway mediated by Ras and a kinase cascade that includes Raf, Mek and MAPK. Activation of this cascade is positively regulated by a number of proteins such as KSR (kinase suppressor of Ras), SUR-8/SOC-2, SUR-6/PP2A-B and CDF-1. We describe the functional characterization of sur-7 and several gene...

C57BL/6 is a well-characterized mouse strain that is used extensively for immunological and neurological research. The establishment of C57BL/6 ES cell lines has facilitated the study of gene-altered mice in a pure genetic background-however, relatively few such lines exist. Using a defined media supplement, knockout serum replacement (KSR) with knockout DMEM (KSR-KDMEM), we find that we can re...

The paper investigates the eeective performance attainable for a speciic class of application programs on shared memory supercomputers. Speciically, we are to investigate how seismic data analysis applications behave on the Kendall Square Research Inc.'s KSR multiprocessors. The computational kernel of seismic computation algorithms is parallelized and its performance is analyzed. Three approac...