The polyacetylene falcarinol, isolated from carrots, has been shown to be protective against chemically induced colon cancer development in rats, but the mechanisms are not fully understood. In this study CaCo-2 cells were exposed to falcarinol (0.5-100 microM) and the effects on proliferation, DNA damage, and apoptosis investigated. Low-dose falcarinol exposure (0.5-10 microM) decreased expres...

objective: many psychodynamic oriented psychotherapists believe that people do not become addicted without a reason they use drugs to avoid painful feelings, thoughts and memories. the present study examines the relationship between the level of dissociation, substance dependence disorder and other psychiatric disorder. methods: in a descriptive study on prisoners of adel-abad prison, shiraz, i...

F or approaching the truth about the clinical phenomenon of tinnitus from more and more possible aspects, it is important in the sense of the old Aristotelean systematics of scientific thinking to choose various and alternating directions for regarding the phenomenon. Therefore, today I am also choosing a biochemical angle of view. Our model of good and bad hearing, ear noise or tinnitus , is p...

Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human li...

The Pedersen-Freed theory for chemically induced dynamic spin polarization CIDN(E)P is generalized to include the effects of anisotropic reactivities and anisotropic exchange interactions on the radical-pair mechanism. Detailed results are given for the simple case in which only one radical exhibits anisotropy that is approximated by a cosine distribution, and the rotational and translational m...

Neural mechanisms underlying the onset and maintenance of epileptic seizures involve alterations in inhibitory and/or excitatory neurotransmitter pathways. Thus, the prospecting of novel molecules from natural products that target both inhibition and excitation systems has deserved interest in the rational design of new anticonvulsants. We isolated the alkaloids (+)-erythravine and (+)-11-α-hyd...

Oxidative stress remains one of the most well studied, albeit somewhat contentious, causes of age-related changes in humans. Consequently, a large number of putative antioxidant compounds are freely available in myriad formulations that are often not tested for their efficacy or regulated for quality control. Following the development of a Drosophila model of oxidative-stress dependent aging (p...