Organic solvents are constantly present in the pharmaceutical production processes. They are usually used at any step of the synthesis pathway during the drug product formulation process. Organic solvents play an important role in the pharmaceutical industry, and appropriate selection of the solvents for the synthesis of drug substance may enhance the yield, or determine characteristics such as...

Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources...

This Account reports the synthesis and characterization of dendrimer-encapsulated metal nanoparticles and their applications to catalysis. These materials are prepared by sequestering metal ions within dendrimers followed by chemical reduction to yield the corresponding zerovalent metal nanoparticle. The size of such particles depends on the number of metal ions initially loaded into the dendri...

Since environmental pollution caused by chemical and energy industries has increased for several decades, there is a social expectation that scientists and engineers try to design sustainable chemical processes, to generate less hazardous materials and more environmentally friendly sources of energy production. In this review the roles of Ionic Liquids (ILs) and IL based solvent systems as prop...

background: solvents, which are widely used in industry, are able to dissolve another substance for creating a solution. solvents have various effects on human health based on their type and chemical composition. methods: this was a cross-sectional study to investigate the harmful effects of solvents on wood painters in yazd city. to achieve information, a census questionnaire was prepared and ...

The solvent plays an important role in a given chemical reaction. Since most reaction in nature occur in the mixed-solvent systems, a comprehensive principle for solvent optimization was required. By calculating the Hansen solubility parameters (HSP) distance Ra, we designed a model experiment to explore the influence of mixed solvents on the chemical synthesis. The synthesis of polydopamine (P...

Alkyl glycosides are biodegradable surfactants with excellent physico-chemical properties. Although their wide-range application is considered ecofriendly, synthesis not due to the need for toxic organic solvents and corrosive acids as catalysts. Moreover, chemical results in complex mixtures rather than defined compounds. To overcome both disadvantages well limited solubility of sugars solvent...

In this research, Quantum-mechanical calculations were performed at the HF method with the 6-31+G*basis set and at the B3LYP method with the 6-31+G* basis set in the gas phase and five solvents such as water, DMSO, methanol, ethanol and dichloromethane at six temperatures. According to these theoretical results of IR, we extracted thermo chemical parameters such as enthalpy (∆H Kcal/mol), Gibbs...