The influence of several chelating agents (CaDTPA, ZnDTPA, CaEDTA, ZnEDTA, DMSA, D-penicillamine and DMPS, DMP and DDC) on the acute toxicity of CdCl2 and on the whole body retention and tissue distribution of cadmium after the IV application of 115mCdCl2 was compared in mice. The chelating agents were applied immediately after the application of cadmium. CaDTPA, ZnDTPA and DMSA appeared to be ...

The quantitative manipulation of intracellular calcium concentration ([Ca(2+)](i)) is a valuable instrument in the modern cell biologists' toolbox for unraveling the many cell processes controlled by calcium. I summarize here the major classes of photosensitive calcium chelators used to elevate or reduce [Ca(2+)](i), with an emphasis on their physicochemical properties and methods of calculatin...

Aspects of the kinetics and thermodynamics of the iron-catalysed Haber-Weiss reaction are discussed with special emphasis on the potential in vivo sources of iron. In addition, the properties of the iron chelates that inhibit the Haber-Weiss reaction are considered.

BACKGROUND Researchers are exploring the effects of adding treatments to the main antimalarial regimens in an attempt to reduce mortality from Plasmodium falciparum. Iron chelation is one potential chemotherapeutic adjuvant treatment. Before advocating adjunctive therapy, the effects of iron chelators in improving patient outcomes need to be examined. OBJECTIVES To assess the effects of iron-...