The nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, Nup54, Nup58, and Nup62. However, the structure and composition of the channel are elusive. We determined the crystal structures of the interacting domains between these nucleoporins and pieced together the molecular architecture of the mammalian transport chan...

The action potential of the unmyelinated nerve is metabolically expensive. Using the energetic cost per unit length for the biophysically modeled action potential of the squid giant axon, we analyze this cost and identify one possible optimization. The energetic cost arising from an action potential is divided into three separate components: 1) the depolarization of the rising phase; 2) the hyp...

In the Lyme disease spirochete Borrelia burgdorferi, the outer membrane protein P66 is capable of pore formation with an atypical high single-channel conductance of 11 nS in 1 M KCl, which suggested that it could have a larger diameter than 'normal' Gram-negative bacterial porins. We studied the diameter of the P66 channel by analyzing its single-channel conductance in black lipid bilayers in t...

Knowledge of habitat requirements of aquatic animals plays an important role in fisheries and protection programs of aquatic ecosystems. Hence, this study was conducted to investigate the suitability indexes of habitat use and habitat suitability index (HSI) of Barbus cyri in its distribution range in Tootkabon River. A number of environmental variables, including elevation, water depth, river ...

Experiments were performed to test the hypothesis that oxidative stress underlies the enhanced tonic dilator impact of inward-rectifier K(+) channels on renal afferent arterioles of rats with streptozotocin-induced diabetes mellitus. Sham and diabetic rats were left untreated or provided Tempol in their drinking water for 26±1 days, after which afferent arteriolar lumen diameter and its respons...

among different spd techniques, equal channel angular pressing has attracted the most attentions,because of applying large strain to solid bulk materials. in this research, ecap process up to 6passes was carried out on a pure copper and a 6012 al-mg-si alloy with bc route in ecap dieswith φ=120 and ψ=20 and diameter of 20and 10 millimeter respectively. moreover, x-raydiffraction (xrd) system wa...

modeling the hydraulic geometry of gravel rivers is of intrest to hydraulic engineers, hydrologists and enviromental scientists who are engaged in predicting the adjustments of an alluvial channel to an altered upstream runoff or sediment supply. the widely used qualitative and regime models, while indicating the general direction of river adjustment, are not able to deal with river response at...

The effect of diameter variation on electrical characteristics of long-channel InAs nanowire metal-oxide-semiconductor field-effect transistors is experimentally investigated. For a range of nanowire diameters, in which significant band gap changes are observed due to size quantization, the Schottky barrier heights between source/drain metal contacts and the semiconducting nanowire channel are ...

Surface-architecture-controlled ZnO nanowires were grown using a vapor transport method on various ZnO buffer film coated c-plane sapphire substrates with or without Au catalysts. The ZnO nanowires that were grown showed two different types of geometric properties: corrugated ZnO nanowires having a relatively smaller diameter and a strong deep-level emission photoluminescence (PL) peak and smoo...

        In the present study, the effect of random distribution of reactants and products on laminar, 2D and steady-state flame propagation in aluminium particles has been investigated. The equations are solved only for lean mixture. The flame structure is assumed to consist of a preheat zone, a reaction zone and a post flame zone. It is presumed that in the preheat zone particles are heated an...