AIMS The depressor action of the centrally antihypertensive drug moxonidine has been attributed to activation of I(1)-imidazoline receptor in the rostral ventrolateral medulla (RVLM). The objective of this study was to determine the role of the γ-aminobutyric acid (GABA) mechanisms in the RVLM in mediating the effect of moxonidine in anaesthetized normotensive rats. METHODS AND RESULTS The re...

In the cerebellar glomerulus, GABAergic synapses formed by Golgi cells regulate excitatory transmission from mossy fibers to granule cells through feed-forward and feedback mechanisms. In acute cerebellar slices, we found that stimulating Golgi cell axons with a train of 10 impulses at 100 Hz transiently inhibited both the phasic and the tonic components of inhibitory responses recorded in gran...

Fear can be considered as a functional defense behavior to protect living beings against dangerous situation. In our studies we have investigated the fear behavior in rats in elevated plus maze .The increase in two parameters percent of open arm entries (%OAE) and percent of time spent in the open arms (% OAT) and decrease in the percent of time spent in closed arm (%CAT) was considered as fear...

Fear can be considered as a functional defense behavior to protect living beings against dangerous situation. In our studies we have investigated the fear behavior in rats in elevated plus maze .The increase in two parameters percent of open arm entries (%OAE) and percent of time spent in the open arms (% OAT) and decrease in the percent of time spent in closed arm (%CAT) was considered as fear...

Background and aims: The Anterior Pretectal Nucleus (APN) is a structure from which descending pathways originate and act to modulate spinal noxious inputs. Previous experiments indicate that serotonergic and opioid, but not muscarinic cholinergic receptors in the APN participate in descending inhibitory modulation of pain. Villarreal and Prado (2007) suggested that the activation of a serotone...

Seutin, Vincent, Laurent Massotte, Jacqueline Scuvée-Moreau, ena observed in our study were due to the anesthetic, some (n Å 16) neonatal rats were killed without prior anesthesia. The other and Albert Dresse. Spontaneous apamin-sensitive hyperpolarizations in dopaminergic neurons of neonatal rats. J. Neurophysiol. animals were anesthetized with halothane. All animals were decapitated. 80: 3361...

In vivo effects of GABA(B) receptor-positive modulators suggest that they have therapeutic potential for treating central nervous system disorders such as anxiety, depression, and drug abuse. Although these effects generally are thought to be mediated by positive modulation of GABA(B) receptors, such modulation has been examined primarily in vitro. The present study was aimed at further examini...

the objective of the present investigation was to assess the possible involvement ofgabaergic mechanism in analgesic effect of aqueous extract of origanum vulgare (org)in a rat model of acute pain test. sixty-three anaesthetized male wistar rats (200-250 g) werecannulated into the left ventricle. five to seven days after the recovery from surgery, org extractwas intraventricularly injected at d...