Thalamic pain syndrome, a type of central post-stroke pain (CPSP), may develops after a hemorrhagic or ischemic stroke and results in impairment of the thalamus. There is limited experience about gabapentin in treatment of central pains like CPSP.In a prospective observational study, the intensity of pain was recorded using the Numeric Rating Scale (NRS) at the entrance to the study. Patients e...

background: to determine whether islamic fasting would change cerebral blood flow during ramadan. methods: the study group comprised 20 subjects (16 males and 4 females) on a regimen of 1 month food and water intake restriction, according to islamic fasting ritual. subjects were evaluated for cerebral bolo flow through a middle cerebral artery (mca) by means of transcranial doppler (tcd), the d...

BACKGROUND In recent years, cerebrovascular disease has been the leading cause of death and adult disability in the world. This study describes an efficient approach to detect cerebrovascular disease. OBJECTIVE In order to improve cerebrovascular treatment, prevention, and care, an automatic cerebrovascular disease detection eHealth platform is designed and studied. METHODS We designed an a...

OBJECTIVE To study neurologic complications after heart transplant. DESIGN Retrospective cohort study. SETTING Cardiac transplant program at Mayo Clinic, Rochester, Minnesota. PATIENTS We retrospectively studied 313 patients who underwent heart transplant at Mayo Clinic Rochester from January 1, 1988, through October 31, 2006. MAIN OUTCOME MEASURES Neurologic symptoms, neurologic compli...

Breakdowns of the blood–brain barrier (BBB) are frequently associated with various central nervous system (CNS) diseases. Cerebrovascular endothelial cells (ECs) play important roles in maintaining a stable microenvironment for the CNS by interacting with pericytes. However, the genetic mechanisms controlling the functions of cerebral ECs are still largely unknown. Here, we report that disrupti...

Breakdowns of the blood–brain barrier (BBB) are frequently associated with various central nervous system (CNS) diseases. Cerebrovascular endothelial cells (ECs) play important roles in maintaining a stable microenvironment for the CNS by interacting with pericytes. However, the genetic mechanisms controlling the functions of cerebral ECs are still largely unknown. Here, we report that disrupti...

Although the pathogenesis of cardio-cerebrovascular disease (CCVD) is multifactorial, an increasing number of experimental and clinical studies have highlighted the importance of histone deacetylase (HDAC)-mediated epigenetic processes in the development of cardio-cerebrovascular injury. HDACs are a family of enzymes to balance the acetylation activities of histone acetyltransferases on chromat...

Thalamic pain syndrome, a type of central post-stroke pain (CPSP), may develops after a hemorrhagic or ischemic stroke and results in impairment of the thalamus. There is limited experience about gabapentin in treatment of central pains like CPSP.In a prospective observational study, the intensity of pain was recorded using the Numeric Rating Scale (NRS) at the entrance to the study. Patients e...